TY - JOUR
T1 - Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children
AU - Zuccotti, Gian Vincenzo
AU - Vigano, Alessandra
AU - Borelli, Manuela
AU - Saresella, Marina
AU - Giacomet, Vania
AU - Clerici, Mario
PY - 2007/3
Y1 - 2007/3
N2 - Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P = 0.01) and killing (P = 0.009), Toll-like receptor 2 expression (P = 0.01) and the interleukin-12/interleukin-10 ratio (P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.
AB - Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P = 0.01) and killing (P = 0.009), Toll-like receptor 2 expression (P = 0.01) and the interleukin-12/interleukin-10 ratio (P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.
KW - HIV
KW - Immunology
KW - Innate immunity
KW - Lactoferrin
KW - Phagocytosis
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UR - http://www.scopus.com/inward/citedby.url?scp=33846928985&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2006.11.017
DO - 10.1016/j.ijantimicag.2006.11.017
M3 - Article
C2 - 17276659
AN - SCOPUS:33846928985
VL - 29
SP - 353
EP - 355
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 3
ER -