Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children

Gian Vincenzo Zuccotti, Alessandra Vigano, Manuela Borelli, Marina Saresella, Vania Giacomet, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P = 0.01) and killing (P = 0.009), Toll-like receptor 2 expression (P = 0.01) and the interleukin-12/interleukin-10 ratio (P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.

Original languageEnglish
Pages (from-to)353-355
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • HIV
  • Immunology
  • Innate immunity
  • Lactoferrin
  • Phagocytosis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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