Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children

Gian Vincenzo Zuccotti; Alessandra Vigano; Manuela Borelli; Marina Saresella; Vania Giacomet; Mario Clerici

doi:10.1016/j.ijantimicag.2006.11.017

Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children

Gian Vincenzo Zuccotti, Alessandra Vigano, Manuela Borelli, Marina Saresella, Vania Giacomet, Mario Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P = 0.01) and killing (P = 0.009), Toll-like receptor 2 expression (P = 0.01) and the interleukin-12/interleukin-10 ratio (P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.

Original language	English
Pages (from-to)	353-355
Number of pages	3
Journal	International Journal of Antimicrobial Agents
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.ijantimicag.2006.11.017
Publication status	Published - Mar 2007

Keywords

HIV
Immunology
Innate immunity
Lactoferrin
Phagocytosis

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

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10.1016/j.ijantimicag.2006.11.017

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Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children. / Zuccotti, Gian Vincenzo; Vigano, Alessandra; Borelli, Manuela; Saresella, Marina; Giacomet, Vania; Clerici, Mario.

In: International Journal of Antimicrobial Agents, Vol. 29, No. 3, 03.2007, p. 353-355.

Research output: Contribution to journal › Article › peer-review

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abstract = "Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-na{\"i}ve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P = 0.01) and killing (P = 0.009), Toll-like receptor 2 expression (P = 0.01) and the interleukin-12/interleukin-10 ratio (P = 0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.",

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AU - Saresella, Marina

AU - Giacomet, Vania

AU - Clerici, Mario

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