TY - JOUR
T1 - Modulation of intracortical inhibition induced by low- and high-frequency repetitive transcranial magnetic stimulation
AU - Fierro, B.
AU - Piazza, A.
AU - Brighina, F.
AU - La Bua, V.
AU - Buffa, D.
AU - Oliveri, M.
PY - 2001
Y1 - 2001
N2 - We studied the changes of duration of subsequent silent periods (SPs) during repetitive magnetic stimulation (rTMS) trains of ten stimuli delivered at low (1 Hz) and high (7 Hz) frequencies. The effects at different intensities of stimulation (motor threshold, MT, 115% and 130% above the MT) were also evaluated. rTMS was performed in eight healthy subjects with a figure-of-eight coil placed over the hand motor area. The SP was recorded from abductor pollicis brevis (APB) muscle during a voluntary contraction of 30% of maximum effort. rTMS at 1-Hz frequency progressively decreased the duration of SP, whereas an alternating pattern of smaller and larger values was observed during trains at 7-Hz frequency and higher stimulus intensity. The findings show that rTMS changes the duration of cortical SPs; the effect is probably due to the modulation of intracortical inhibitory interneurons depending on the frequency and intensity of stimulation.
AB - We studied the changes of duration of subsequent silent periods (SPs) during repetitive magnetic stimulation (rTMS) trains of ten stimuli delivered at low (1 Hz) and high (7 Hz) frequencies. The effects at different intensities of stimulation (motor threshold, MT, 115% and 130% above the MT) were also evaluated. rTMS was performed in eight healthy subjects with a figure-of-eight coil placed over the hand motor area. The SP was recorded from abductor pollicis brevis (APB) muscle during a voluntary contraction of 30% of maximum effort. rTMS at 1-Hz frequency progressively decreased the duration of SP, whereas an alternating pattern of smaller and larger values was observed during trains at 7-Hz frequency and higher stimulus intensity. The findings show that rTMS changes the duration of cortical SPs; the effect is probably due to the modulation of intracortical inhibitory interneurons depending on the frequency and intensity of stimulation.
KW - Human
KW - Intracortical inhibition Motor evoked potentials
KW - Repetitive transcranial magnetic stimulation Silent period
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U2 - 10.1007/s002210100728
DO - 10.1007/s002210100728
M3 - Article
C2 - 11465743
AN - SCOPUS:0035000309
VL - 138
SP - 452
EP - 457
JO - Experimental Brain Research
JF - Experimental Brain Research
SN - 0014-4819
IS - 4
ER -