Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation

Susanna Soarpa, Gabriella D'Orazi, Maria Ragano-Caracciolo, Pierluigi Cardelli, Laura Masuelli, Andrea Modesti

Research output: Contribution to journalArticlepeer-review

Abstract

A comparable pattern of morphological neuronal differentiation was induced in the human neuroblastoma cell line SMS-KCNR by treatment with either retinoic acid (RA) or exogenous laminin (LM). LM expression and synthesis by SMS-KCNR was increased upon RA treatment which involved the cell bound, rather than the secreted protein. These data suggest an involvement of LM in the neuroblastoma differentiation process manifested both as an ability of LM to induce a morphological neuronal differentiation and as a selective control on LM metabolism during RA induced neuronal differentiation.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalCancer Letters
Volume64
Issue number1
DOIs
Publication statusPublished - May 30 1992

Keywords

  • differentiation
  • laminin
  • neuroblastoma
  • retinoic acid

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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