Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation

Susanna Soarpa; Gabriella D'Orazi; Maria Ragano-Caracciolo; Pierluigi Cardelli; Laura Masuelli; Andrea Modesti

doi:10.1016/0304-3835(92)90018-Q

Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation

Susanna Soarpa, Gabriella D'Orazi, Maria Ragano-Caracciolo, Pierluigi Cardelli, Laura Masuelli, Andrea Modesti

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

A comparable pattern of morphological neuronal differentiation was induced in the human neuroblastoma cell line SMS-KCNR by treatment with either retinoic acid (RA) or exogenous laminin (LM). LM expression and synthesis by SMS-KCNR was increased upon RA treatment which involved the cell bound, rather than the secreted protein. These data suggest an involvement of LM in the neuroblastoma differentiation process manifested both as an ability of LM to induce a morphological neuronal differentiation and as a selective control on LM metabolism during RA induced neuronal differentiation.

Original language	English
Pages (from-to)	31-37
Number of pages	7
Journal	Cancer Letters
Volume	64
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(92)90018-Q
Publication status	Published - May 30 1992

Keywords

differentiation
laminin
neuroblastoma
retinoic acid

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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title = "Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation",

abstract = "A comparable pattern of morphological neuronal differentiation was induced in the human neuroblastoma cell line SMS-KCNR by treatment with either retinoic acid (RA) or exogenous laminin (LM). LM expression and synthesis by SMS-KCNR was increased upon RA treatment which involved the cell bound, rather than the secreted protein. These data suggest an involvement of LM in the neuroblastoma differentiation process manifested both as an ability of LM to induce a morphological neuronal differentiation and as a selective control on LM metabolism during RA induced neuronal differentiation.",

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T1 - Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation

AU - Soarpa, Susanna

AU - D'Orazi, Gabriella

AU - Ragano-Caracciolo, Maria

AU - Cardelli, Pierluigi

AU - Masuelli, Laura

AU - Modesti, Andrea

PY - 1992/5/30

Y1 - 1992/5/30

N2 - A comparable pattern of morphological neuronal differentiation was induced in the human neuroblastoma cell line SMS-KCNR by treatment with either retinoic acid (RA) or exogenous laminin (LM). LM expression and synthesis by SMS-KCNR was increased upon RA treatment which involved the cell bound, rather than the secreted protein. These data suggest an involvement of LM in the neuroblastoma differentiation process manifested both as an ability of LM to induce a morphological neuronal differentiation and as a selective control on LM metabolism during RA induced neuronal differentiation.

AB - A comparable pattern of morphological neuronal differentiation was induced in the human neuroblastoma cell line SMS-KCNR by treatment with either retinoic acid (RA) or exogenous laminin (LM). LM expression and synthesis by SMS-KCNR was increased upon RA treatment which involved the cell bound, rather than the secreted protein. These data suggest an involvement of LM in the neuroblastoma differentiation process manifested both as an ability of LM to induce a morphological neuronal differentiation and as a selective control on LM metabolism during RA induced neuronal differentiation.

KW - differentiation

KW - laminin

KW - neuroblastoma

KW - retinoic acid

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ER -

Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation

Abstract

Keywords

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