Modulation of macrophage function and metabolism

S. Bellosta, F. Bernini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Several drugs or pharmacologically active molecules such as statins, calcium antagonists, and PPAR agonists have been shown to affect macrophage functions that contribute to atherosclerosis and modulate plaque stability. For example, the modulation of matrix metalloproteinase secretion and cholesterol metabolism in macrophages may help to prevent cardiovascular disease independently of the correction of risk factors.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
Pages665-695
Number of pages31
Volume170
DOIs
Publication statusPublished - 2005

Publication series

NameHandbook of Experimental Pharmacology
Volume170
ISSN (Print)01712004
ISSN (Electronic)18650325

Keywords

  • Atherosclerosis
  • Cholesterol metabolism
  • Drug treatment
  • Inflammation
  • Matrix metalloproteinase
  • Pleiotropic effects

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

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