Modulation of macrophage function and metabolism

S. Bellosta; F. Bernini

doi:10.1007/3-540-27661-0-25

Modulation of macrophage function and metabolism

S. Bellosta, F. Bernini

IRCCS Multimedica

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Several drugs or pharmacologically active molecules such as statins, calcium antagonists, and PPAR agonists have been shown to affect macrophage functions that contribute to atherosclerosis and modulate plaque stability. For example, the modulation of matrix metalloproteinase secretion and cholesterol metabolism in macrophages may help to prevent cardiovascular disease independently of the correction of risk factors.

Original language	English
Title of host publication	Handbook of Experimental Pharmacology
Pages	665-695
Number of pages	31
Volume	170
DOIs	https://doi.org/10.1007/3-540-27661-0-25
Publication status	Published - 2005

Publication series

Name	Handbook of Experimental Pharmacology
Volume	170
ISSN (Print)	01712004
ISSN (Electronic)	18650325

Keywords

Atherosclerosis
Cholesterol metabolism
Drug treatment
Inflammation
Matrix metalloproteinase
Pleiotropic effects

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Biochemistry

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10.1007/3-540-27661-0-25

Cite this

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title = "Modulation of macrophage function and metabolism",

abstract = "Several drugs or pharmacologically active molecules such as statins, calcium antagonists, and PPAR agonists have been shown to affect macrophage functions that contribute to atherosclerosis and modulate plaque stability. For example, the modulation of matrix metalloproteinase secretion and cholesterol metabolism in macrophages may help to prevent cardiovascular disease independently of the correction of risk factors.",

keywords = "Atherosclerosis, Cholesterol metabolism, Drug treatment, Inflammation, Matrix metalloproteinase, Pleiotropic effects",

author = "S. Bellosta and F. Bernini",

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AU - Bernini, F.

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AB - Several drugs or pharmacologically active molecules such as statins, calcium antagonists, and PPAR agonists have been shown to affect macrophage functions that contribute to atherosclerosis and modulate plaque stability. For example, the modulation of matrix metalloproteinase secretion and cholesterol metabolism in macrophages may help to prevent cardiovascular disease independently of the correction of risk factors.

KW - Atherosclerosis

KW - Cholesterol metabolism

KW - Drug treatment

KW - Inflammation

KW - Matrix metalloproteinase

KW - Pleiotropic effects

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Modulation of macrophage function and metabolism

Abstract

Publication series

Keywords

ASJC Scopus subject areas

Access to Document

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