Some investigators have proposed myoblast transfer as a potential therapy for the treatment of Duchenne muscular dystrophy. Little is known about the immunobiology of myoblast transplantation. Transplantation rejection is mediated to a large extent by CD8+ T cells, which recognize alloantigens encoded by class IHL A genes, and by CD4+ T cells, which recognize alloantigens encoded by class II HLA genes. Gamma interferon (IFN-γ) is a potent inducer of HLA class II molecules as well as β2-microglobulin, which is co-expressed with HLA class I. IFN-γ may be a critical cytokine involved in graft rejection. We purified human myoblasts by flow cytometry and incubated them in vitro for varying time periods with recombinant human IFN-γ. The inducibility of HLA-DR and -DP molecules raises a note of caution concerning possible rejection phenomenon which might occur following myoblast transplantation.
|Number of pages||5|
|Publication status||Published - 1991|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology