Abstract
The effects of the glucocorticoid hormones prednisone (PDN) and deflazacort (DFC) on MHC gene products membrane expression and mRNA level were evaluated on peripheral blood lymphocytes and on the melanoma M14 cell line. The modulatory effect of the association of PDN and DFC with interferon-γ was also evaluated. PDN and DFC inhibited MHC gene expression in lymphocytes and M14 cells both on the cell membrane and at the mRNA level. Interferon-γ was able to counteract this inhibitory effect. These results may contribute to clarify the role played by glucocorticoid hormones in the modulation of immune responses.
| Original language | English |
|---|---|
| Pages (from-to) | 295-301 |
| Number of pages | 7 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 99 |
| Issue number | 2-4 |
| Publication status | Published - 1992 |
Keywords
- Glucocorticoids
- HLA
- Interferon
- Lymphocytes
- Melanoma
- MHC
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy