Modulation of MHC gene expression by glucocorticoid hormones

M. Scudeletti, L. Lanza, P. Contini, F. Puppo, F. Indiveri

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the glucocorticoid hormones prednisone (PDN) and deflazacort (DFC) on MHC gene products membrane expression and mRNA level were evaluated on peripheral blood lymphocytes and on the melanoma M14 cell line. The modulatory effect of the association of PDN and DFC with interferon-γ was also evaluated. PDN and DFC inhibited MHC gene expression in lymphocytes and M14 cells both on the cell membrane and at the mRNA level. Interferon-γ was able to counteract this inhibitory effect. These results may contribute to clarify the role played by glucocorticoid hormones in the modulation of immune responses.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume99
Issue number2-4
Publication statusPublished - 1992

Keywords

  • Glucocorticoids
  • HLA
  • Interferon
  • Lymphocytes
  • Melanoma
  • MHC

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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