Abstract
In the past years, the attention of scientists has focused mainly on the study of the genetic information and alterations that regulate eukaryotic cell proliferation and that lead to neoplastic transformation. All therapeutic strategies against cancer are, to date, directed at DNA either with cytotoxic drugs or gene therapy. Little or no interest has been aroused by protein synthesis mechanisms. However, an increasing body of data is emerging about the involvement of translational processes and factors in control of cell proliferation, indicating that protein synthesis can be an additional target for anticancer strategies. In this paper we review the novel insights on the biochemical and molecular events leading to protein biosynthesis and we describe their involvement in cell proliferation and tumorigenesis. A possible mechanistic explanation is given by the interactions that occur between protein synthesis machinery and the proliferative signal transduction pathways and that are therefore suitable targets for indirect modulation of protein synthesis. We briefly describe the molecular tools used to block protein synthesis and the attempts made at increasing their efficacy. Finally, we propose a new multimodal strategy against cancer based on the simultaneous intervention on protein synthesis and signal transduction.
| Original language | English |
|---|---|
| Pages (from-to) | 3919-3936 |
| Number of pages | 18 |
| Journal | European Journal of Biochemistry |
| Volume | 267 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Signal transduction
- Therapy
- Translation
- Tumour
ASJC Scopus subject areas
- Biochemistry
Cite this
Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation. / Caraglia, Michele; Budillon, Alfredo; Vitale, Giovanni; Lupoli, Giovanni; Tagliaferri, Pierosandro; Abbruzzese, Alberto.
In: European Journal of Biochemistry, Vol. 267, No. 13, 2000, p. 3919-3936.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation
AU - Caraglia, Michele
AU - Budillon, Alfredo
AU - Vitale, Giovanni
AU - Lupoli, Giovanni
AU - Tagliaferri, Pierosandro
AU - Abbruzzese, Alberto
PY - 2000
Y1 - 2000
N2 - In the past years, the attention of scientists has focused mainly on the study of the genetic information and alterations that regulate eukaryotic cell proliferation and that lead to neoplastic transformation. All therapeutic strategies against cancer are, to date, directed at DNA either with cytotoxic drugs or gene therapy. Little or no interest has been aroused by protein synthesis mechanisms. However, an increasing body of data is emerging about the involvement of translational processes and factors in control of cell proliferation, indicating that protein synthesis can be an additional target for anticancer strategies. In this paper we review the novel insights on the biochemical and molecular events leading to protein biosynthesis and we describe their involvement in cell proliferation and tumorigenesis. A possible mechanistic explanation is given by the interactions that occur between protein synthesis machinery and the proliferative signal transduction pathways and that are therefore suitable targets for indirect modulation of protein synthesis. We briefly describe the molecular tools used to block protein synthesis and the attempts made at increasing their efficacy. Finally, we propose a new multimodal strategy against cancer based on the simultaneous intervention on protein synthesis and signal transduction.
AB - In the past years, the attention of scientists has focused mainly on the study of the genetic information and alterations that regulate eukaryotic cell proliferation and that lead to neoplastic transformation. All therapeutic strategies against cancer are, to date, directed at DNA either with cytotoxic drugs or gene therapy. Little or no interest has been aroused by protein synthesis mechanisms. However, an increasing body of data is emerging about the involvement of translational processes and factors in control of cell proliferation, indicating that protein synthesis can be an additional target for anticancer strategies. In this paper we review the novel insights on the biochemical and molecular events leading to protein biosynthesis and we describe their involvement in cell proliferation and tumorigenesis. A possible mechanistic explanation is given by the interactions that occur between protein synthesis machinery and the proliferative signal transduction pathways and that are therefore suitable targets for indirect modulation of protein synthesis. We briefly describe the molecular tools used to block protein synthesis and the attempts made at increasing their efficacy. Finally, we propose a new multimodal strategy against cancer based on the simultaneous intervention on protein synthesis and signal transduction.
KW - Signal transduction
KW - Therapy
KW - Translation
KW - Tumour
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UR - http://www.scopus.com/inward/citedby.url?scp=0001618425&partnerID=8YFLogxK
U2 - 10.1046/j.1432-1327.2000.01465.x
DO - 10.1046/j.1432-1327.2000.01465.x
M3 - Article
VL - 267
SP - 3919
EP - 3936
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
SN - 0014-2956
IS - 13
ER -