Modulation of polyfunctional HIV-specific CD8 T cells in patients responding differently to antiretroviral therapy

Rita Casetti, G. De Simone, A. Sacchi, V. Bordoni, D. Viola, A. Rinaldi, C. Agrati, C. Gioia, F. Martini

Research output: Contribution to journalArticlepeer-review

Abstract

Antiretroviral therapy allows a restoration of immune cell homeostasis associated with a normal immune competence. Our goal was to analyze the modulation of polyfunctional HIV-specific CD8+ T-cell responses during antiretroviral therapy. HIV-infected individuals were divided into four groups according to CD4+ cell count and viral load at the moment of recruitment. Whole blood was stimulated with a pool of CD8-specific HIV-antigens to assess cytokine/chemokine production and cytotoxicity activity by using flow cytometry. The groups show different modulation in HIV-specific CD8+ T-cell responses. In particular, immunological failure showed different distributions of polyfunctional HIV-specific CD8+ responses, mainly due to an increase of cells producing CD107a/IFNγ/IL-2/MIP-1β. Our results indicate that this particular 4+ functional subset is a possible correlate of immunological failure. Considering the complexity of interactions among HAART, immune system and HIV, work is in progress to find correlates of therapy efficacy.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalInternational Journal of Immunopathology and Pharmacology
Volume27
Issue number2
Publication statusPublished - 2014

Keywords

  • Antiretroviral therapy
  • CD8 T-cell response
  • HIV
  • Immune response
  • Polyfunctionality

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

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