Modulation of proliferative activity and amino acid transport in chick embryo hepatocytes by EGF and retinoic acid.

F. Terenzi, L. Falasca, M. Marino, R. Mele, G. Velardi, L. Conti Devirgiliis

Research output: Contribution to journalArticle

Abstract

In this work, the proliferative activity of chick embryo hepatocytes and its regulation by factors affecting cell growth, such as epidermal growth factor (EGF) and retinoic acid, were studied. The transport of nutritional molecules, like amino acids, was also investigated; in particular, the uptake mediated by the Na+ -dependent system A, known to be under hormonal and growth factor control. Moreover, some steps in the transduction pathway of mitogenic signal were analyzed, both for EGF and retinoic acid treatment. Results obtained suggest that chick embryo hepatocytes growth in an exclusive serum dependent way shows an early sensibility to EGF stimulation as regards to the proliferative activity and amino acid transport, responds to retinoic acid treatment and lack of contact inhibition. Moreover, as far as the signal transduction is concerned, at early stages, they do not seem to be able to utilize the same signal molecules as observed in adult life.

Original languageEnglish
Pages (from-to)861-871
Number of pages11
JournalCellular and Molecular Biology
Volume43
Issue number6
Publication statusPublished - Sep 1997

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Chick Embryo
Tretinoin
Epidermal Growth Factor
Hepatocytes
Modulation
Amino Acids
Signal Transduction
Contact Inhibition
Signal transduction
Molecules
Cell growth
Growth
Intercellular Signaling Peptides and Proteins
Serum

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Modulation of proliferative activity and amino acid transport in chick embryo hepatocytes by EGF and retinoic acid. / Terenzi, F.; Falasca, L.; Marino, M.; Mele, R.; Velardi, G.; Conti Devirgiliis, L.

In: Cellular and Molecular Biology, Vol. 43, No. 6, 09.1997, p. 861-871.

Research output: Contribution to journalArticle

Terenzi, F, Falasca, L, Marino, M, Mele, R, Velardi, G & Conti Devirgiliis, L 1997, 'Modulation of proliferative activity and amino acid transport in chick embryo hepatocytes by EGF and retinoic acid.', Cellular and Molecular Biology, vol. 43, no. 6, pp. 861-871.
Terenzi, F. ; Falasca, L. ; Marino, M. ; Mele, R. ; Velardi, G. ; Conti Devirgiliis, L. / Modulation of proliferative activity and amino acid transport in chick embryo hepatocytes by EGF and retinoic acid. In: Cellular and Molecular Biology. 1997 ; Vol. 43, No. 6. pp. 861-871.
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