Modulation of tamoxifen-specific binding sites and estrogen receptors by estradiol and progesterone in the neonatal uterus of guinea pig

A. Gulino, J. R. Pasqualini

Research output: Contribution to journalArticlepeer-review

Abstract

Estradiol administration to newborn guinea pigs (30 ng/g body wt) provokes an 84 ± 10% and 145 ± 10% (means ± SE) increase of tamoxifen-specific binding site (site B) in the uterine cytosol and in the 0.6 M KCl nuclear extract, respectively, 48 hr after hormone administration. The simultaneous injection of progesterone (15 μg/g body wt) with estradiol antagonizes this estrogen-induced increase of site B. Parallel modifications of estrogen receptor are observed following the same estradiol treatment: after translocation to the nuclear fraction, cytoplasmic estrogen receptor is replenished 24 hr after hormone administration with a net increase of 60 ± 10% (mean ± SE) after 48 hr. The increase of estrogen receptor is also antagonized by the simultaneous administration of progesterone. It is concluded that the levels of both tamoxifen-specific binding site and estrogen receptor are modulated by estradiol and progesterone in the neonatal uterus of guinea pig.

Original languageEnglish
Pages (from-to)1871-1873
Number of pages3
JournalEndocrinology
Volume112
Issue number5
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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