Modulation of temporal summation threshold of the nociceptive withdrawal reflex by transcutaneous spinal direct current stimulation in humans

A. Perrotta, M. Bolla, M. G. Anastasio, M. Serrao, G. Sandrini, F. Pierelli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: Transcutaneous spinal direct current stimulation (tsDCS) modulates spinal cord pain pathways. The study is aimed to clarify the neurophysiology of the tsDCS-induced modulation of the spinal cord pain processing by evaluating the effect of the tsDCS on temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR). Methods: In a randomized, double-blind, crossover study the effects of anodal, cathodal and sham tsDCS (2. mA, 15. min) applied on the skin overlying the thoracic spinal cord were investigated in 10 healthy subjects. Results: Anodal tsDCS induced a long-lasting (up to 60. min) increase in TST of the NWR as well as a parallel decrease in related psychophysical temporal summation of pain, while cathodal and sham tsDCS resulted ineffective. Conclusions: Anodal tsDCS represents a non-invasive tool able to induce an early and long-lasting depression of the transitory facilitation of the wide dynamic range neurons activity at the basis of both the temporal summation of the NWR and the related temporal summation of pain sensation. Significance: The modulation of the temporal processing of nociceptive stimuli could be effective in treating clinical pain conditions in which pain is generated by spinal cord structures.

Original languageEnglish
JournalClinical Neurophysiology
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Reflex
Pain
Spinal Cord
Spinal Cord Stimulation
Neurophysiology
Double-Blind Method
Cross-Over Studies
Healthy Volunteers
Thorax
Neurons
Skin

Keywords

  • Nociceptive withdrawal reflex
  • Temporal summation
  • Transcutaneous spinal direct current stimulation
  • Wide dynamic range neurons

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

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title = "Modulation of temporal summation threshold of the nociceptive withdrawal reflex by transcutaneous spinal direct current stimulation in humans",
abstract = "Objective: Transcutaneous spinal direct current stimulation (tsDCS) modulates spinal cord pain pathways. The study is aimed to clarify the neurophysiology of the tsDCS-induced modulation of the spinal cord pain processing by evaluating the effect of the tsDCS on temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR). Methods: In a randomized, double-blind, crossover study the effects of anodal, cathodal and sham tsDCS (2. mA, 15. min) applied on the skin overlying the thoracic spinal cord were investigated in 10 healthy subjects. Results: Anodal tsDCS induced a long-lasting (up to 60. min) increase in TST of the NWR as well as a parallel decrease in related psychophysical temporal summation of pain, while cathodal and sham tsDCS resulted ineffective. Conclusions: Anodal tsDCS represents a non-invasive tool able to induce an early and long-lasting depression of the transitory facilitation of the wide dynamic range neurons activity at the basis of both the temporal summation of the NWR and the related temporal summation of pain sensation. Significance: The modulation of the temporal processing of nociceptive stimuli could be effective in treating clinical pain conditions in which pain is generated by spinal cord structures.",
keywords = "Nociceptive withdrawal reflex, Temporal summation, Transcutaneous spinal direct current stimulation, Wide dynamic range neurons",
author = "A. Perrotta and M. Bolla and Anastasio, {M. G.} and M. Serrao and G. Sandrini and F. Pierelli",
year = "2015",
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language = "English",
journal = "Clinical Neurophysiology",
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T1 - Modulation of temporal summation threshold of the nociceptive withdrawal reflex by transcutaneous spinal direct current stimulation in humans

AU - Perrotta, A.

AU - Bolla, M.

AU - Anastasio, M. G.

AU - Serrao, M.

AU - Sandrini, G.

AU - Pierelli, F.

PY - 2015

Y1 - 2015

N2 - Objective: Transcutaneous spinal direct current stimulation (tsDCS) modulates spinal cord pain pathways. The study is aimed to clarify the neurophysiology of the tsDCS-induced modulation of the spinal cord pain processing by evaluating the effect of the tsDCS on temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR). Methods: In a randomized, double-blind, crossover study the effects of anodal, cathodal and sham tsDCS (2. mA, 15. min) applied on the skin overlying the thoracic spinal cord were investigated in 10 healthy subjects. Results: Anodal tsDCS induced a long-lasting (up to 60. min) increase in TST of the NWR as well as a parallel decrease in related psychophysical temporal summation of pain, while cathodal and sham tsDCS resulted ineffective. Conclusions: Anodal tsDCS represents a non-invasive tool able to induce an early and long-lasting depression of the transitory facilitation of the wide dynamic range neurons activity at the basis of both the temporal summation of the NWR and the related temporal summation of pain sensation. Significance: The modulation of the temporal processing of nociceptive stimuli could be effective in treating clinical pain conditions in which pain is generated by spinal cord structures.

AB - Objective: Transcutaneous spinal direct current stimulation (tsDCS) modulates spinal cord pain pathways. The study is aimed to clarify the neurophysiology of the tsDCS-induced modulation of the spinal cord pain processing by evaluating the effect of the tsDCS on temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR). Methods: In a randomized, double-blind, crossover study the effects of anodal, cathodal and sham tsDCS (2. mA, 15. min) applied on the skin overlying the thoracic spinal cord were investigated in 10 healthy subjects. Results: Anodal tsDCS induced a long-lasting (up to 60. min) increase in TST of the NWR as well as a parallel decrease in related psychophysical temporal summation of pain, while cathodal and sham tsDCS resulted ineffective. Conclusions: Anodal tsDCS represents a non-invasive tool able to induce an early and long-lasting depression of the transitory facilitation of the wide dynamic range neurons activity at the basis of both the temporal summation of the NWR and the related temporal summation of pain sensation. Significance: The modulation of the temporal processing of nociceptive stimuli could be effective in treating clinical pain conditions in which pain is generated by spinal cord structures.

KW - Nociceptive withdrawal reflex

KW - Temporal summation

KW - Transcutaneous spinal direct current stimulation

KW - Wide dynamic range neurons

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