Modulation of the constitutive or cytokine-induced bronchial epithelial cell functions in vitro by fluticasone propionate

Federica Sabatini, Michela Silvestri, Rosa Sale, Laura Serpero, Maria E. Raynal, Patrizia Di Blasi, Giovanni A. Rossi

Research output: Contribution to journalArticle

Abstract

When exposed to proinflammatory mediators, human bronchial epithelial cells (HBECs) upregulate the 'constitutive' adhesion molecule expression and cytokine/chemokine release. We tested whether and to what extent the inhibitory effect of fluticasone propionate on HBECs could involve the 'constitutive' and 'cytokine-induced' proinflammatory functions. Stimulation of the HBECs with interleukin (IL)-4 plus tumour necrosis factor (TNF)-α was more effective in upregulating intercellular adhesion molecule (ICAM)-1 (≈2.2-fold increase) than vascular adhesion molecule (VCAM)-1 (≈1.6-fold increase) expression (P

Original languageEnglish
Pages (from-to)215-224
Number of pages10
JournalImmunology Letters
Volume89
Issue number2-3
DOIs
Publication statusPublished - Oct 31 2003

Keywords

  • Adhesion molecules
  • Asthma
  • Chemokines
  • Corticosteroids
  • Cytokines
  • Epithelial cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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