TY - JOUR
T1 - Modulation of the human nociceptive flexion reflex by pleasant and unpleasant odors
AU - Bartolo, Michelangelo
AU - Serrao, Mariano
AU - Gamgebeli, Zurab
AU - Alpaidze, Marina
AU - Perrotta, Armando
AU - Padua, Luca
AU - Pierelli, Francesco
AU - Nappi, Giuseppe
AU - Sandrini, Giorgio
PY - 2013/10
Y1 - 2013/10
N2 - The nociceptive withdrawal reflex (NWR), a defensive response that allows withdrawal from a noxious stimulus, is a reliable index of spinal nociception in humans. It has been shown that various kinds of stimuli (emotional, visual, auditory) can modulate the transmission and perception of pain. The aim of the present study was to evaluate, by means of the NWR, the modulatory effect on the spinal circuitry of olfactory stimuli with different emotional valence. The magnitude of the NWR elicited by electrical stimulation of the sural nerve was measured while 18 subjects (9 women, 9 men) smelled pleasant, unpleasant, or neutral odors. The NWR was conditioned by odor probe with interstimulus intervals (ISIs) of 500 ms and 1,500 ms. The magnitude of NWR was significantly greater after the unpleasant odor probe (P
AB - The nociceptive withdrawal reflex (NWR), a defensive response that allows withdrawal from a noxious stimulus, is a reliable index of spinal nociception in humans. It has been shown that various kinds of stimuli (emotional, visual, auditory) can modulate the transmission and perception of pain. The aim of the present study was to evaluate, by means of the NWR, the modulatory effect on the spinal circuitry of olfactory stimuli with different emotional valence. The magnitude of the NWR elicited by electrical stimulation of the sural nerve was measured while 18 subjects (9 women, 9 men) smelled pleasant, unpleasant, or neutral odors. The NWR was conditioned by odor probe with interstimulus intervals (ISIs) of 500 ms and 1,500 ms. The magnitude of NWR was significantly greater after the unpleasant odor probe (P
KW - Nociceptive withdrawal reflex Nociception Olfactory Odor olfactory stimulation
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U2 - 10.1016/j.pain.2013.06.032
DO - 10.1016/j.pain.2013.06.032
M3 - Article
C2 - 24040974
AN - SCOPUS:84884270058
VL - 154
SP - 2054
EP - 2059
JO - Pain
JF - Pain
SN - 0304-3959
IS - 10
ER -