Modulation of the interictal epileptiform EEG activity during sleep: from oscillations to complex dynamics

R. Ferri, P. Bergonzi, M. Elia, P. Ferri, S. A. Musumeci

Research output: Contribution to journalArticle

Abstract

Polygraphic sleep recordings (EEG, EMG, and EOG) were performed in two groups of epileptic subjects, six with fragile-X syndrome and six with symptomatic epilepsy. Recordings were visually scored for sleep stages and number of spikes/min. Subjects with fragile-X syndrome showed a well defined pattern of production of interictal epileptiform activity with the lowest values during REM sleep; symptomatic epileptic subjects showed less defined and more variable spike/min diagrams. The spectral analysis of the outline of such diagrams confirmed these differences showing shorter periodicties (80-100 min) in the fragile-X group compared to those of the symptomatic group (160-220 min). Finally, a model with multiple feedback circuits is proposed in order to explain the different patterns observed.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalNeurophysiologie Clinique / Clinical Neurophysiology
Volume21
Issue number1
DOIs
Publication statusPublished - 1991

Keywords

  • epilepsy
  • sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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