Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase

Roberto Pellicciari, Laura Amori, Gabriele Costantino, Antonio Giordani, Antonio Macchiarulo, Luisa Mattoli, Paolo Pevarello, Carmela Speciale, Mario Varasi

Research output: Contribution to journalArticlepeer-review

Abstract

A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data support the notion that kynurenine-3-hydroxylase inhibitors may have a sustained therapeutic potential in those diseases characterized by unbalance in the QUIN /KYNA branches of the kynurenine pathway.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume527
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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