TY - JOUR
T1 - Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase
AU - Pellicciari, Roberto
AU - Amori, Laura
AU - Costantino, Gabriele
AU - Giordani, Antonio
AU - Macchiarulo, Antonio
AU - Mattoli, Luisa
AU - Pevarello, Paolo
AU - Speciale, Carmela
AU - Varasi, Mario
PY - 2003
Y1 - 2003
N2 - A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data support the notion that kynurenine-3-hydroxylase inhibitors may have a sustained therapeutic potential in those diseases characterized by unbalance in the QUIN /KYNA branches of the kynurenine pathway.
AB - A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data support the notion that kynurenine-3-hydroxylase inhibitors may have a sustained therapeutic potential in those diseases characterized by unbalance in the QUIN /KYNA branches of the kynurenine pathway.
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M3 - Article
C2 - 15206781
AN - SCOPUS:1042279498
VL - 527
SP - 621
EP - 628
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -