Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase

Roberto Pellicciari; Laura Amori; Gabriele Costantino; Antonio Giordani; Antonio Macchiarulo; Luisa Mattoli; Paolo Pevarello; Carmela Speciale; Mario Varasi

Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase

Roberto Pellicciari, Laura Amori, Gabriele Costantino, Antonio Giordani, Antonio Macchiarulo, Luisa Mattoli, Paolo Pevarello, Carmela Speciale, Mario Varasi

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data support the notion that kynurenine-3-hydroxylase inhibitors may have a sustained therapeutic potential in those diseases characterized by unbalance in the QUIN /KYNA branches of the kynurenine pathway.

Original language	English
Pages (from-to)	621-628
Number of pages	8
Journal	Advances in Experimental Medicine and Biology
Volume	527
Publication status	Published - 2003

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. / Pellicciari, Roberto; Amori, Laura; Costantino, Gabriele; Giordani, Antonio; Macchiarulo, Antonio; Mattoli, Luisa; Pevarello, Paolo; Speciale, Carmela; Varasi, Mario.

In: Advances in Experimental Medicine and Biology, Vol. 527, 2003, p. 621-628.

Research output: Contribution to journal › Article › peer-review

Pellicciari, Roberto ; Amori, Laura ; Costantino, Gabriele ; Giordani, Antonio ; Macchiarulo, Antonio ; Mattoli, Luisa ; Pevarello, Paolo ; Speciale, Carmela ; Varasi, Mario. / Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. In: Advances in Experimental Medicine and Biology. 2003 ; Vol. 527. pp. 621-628.

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