Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase

Roberto Pellicciari, Laura Amori, Gabriele Costantino, Antonio Giordani, Antonio Macchiarulo, Luisa Mattoli, Paolo Pevarello, Carmela Speciale, Mario Varasi

Research output: Contribution to journalArticle

Abstract

A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data support the notion that kynurenine-3-hydroxylase inhibitors may have a sustained therapeutic potential in those diseases characterized by unbalance in the QUIN /KYNA branches of the kynurenine pathway.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume527
Publication statusPublished - 2003

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Kynurenine 3-Monooxygenase
Kynurenine
Neuroprotective Agents
Metabolism
Tryptophan
Modulation
Kynurenic Acid
Gerbillinae
Brain
Plasmas
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pellicciari, R., Amori, L., Costantino, G., Giordani, A., Macchiarulo, A., Mattoli, L., ... Varasi, M. (2003). Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Advances in Experimental Medicine and Biology, 527, 621-628.

Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. / Pellicciari, Roberto; Amori, Laura; Costantino, Gabriele; Giordani, Antonio; Macchiarulo, Antonio; Mattoli, Luisa; Pevarello, Paolo; Speciale, Carmela; Varasi, Mario.

In: Advances in Experimental Medicine and Biology, Vol. 527, 2003, p. 621-628.

Research output: Contribution to journalArticle

Pellicciari, R, Amori, L, Costantino, G, Giordani, A, Macchiarulo, A, Mattoli, L, Pevarello, P, Speciale, C & Varasi, M 2003, 'Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase', Advances in Experimental Medicine and Biology, vol. 527, pp. 621-628.
Pellicciari, Roberto ; Amori, Laura ; Costantino, Gabriele ; Giordani, Antonio ; Macchiarulo, Antonio ; Mattoli, Luisa ; Pevarello, Paolo ; Speciale, Carmela ; Varasi, Mario. / Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. In: Advances in Experimental Medicine and Biology. 2003 ; Vol. 527. pp. 621-628.
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