Modulation of the neurotransmitter release in rat cerebellar neurons by GROβ

Davide Ragozzino, Aldo Giovannelli, Anna Maria Mileo, Cristina Limatola, Angela Santoni, Fabrizio Eusebi

Research output: Contribution to journalArticlepeer-review

Abstract

We report here that, in cultured cerebellar granule cells, the CXC chemokine GROβ stimulates the signaling pathway of the extracellular signal- regulated kinases, and enhances both evoked and spontaneous postsynaptic currents in patch clamped Purkinje neurons from rat cerebellar slices. The GROβ-induced enhancement of the excitatory post-synaptic currents evoked by stimulating the parallel fibres is blocked by the inhibitor of the extracellular signal-regulated kinases pathway PD98059, which also reduces both basal frequency of spontaneous post-synaptic currents and mean amplitude of evoked excitatory post-synaptic currents. Our results suggest that GROβ modulates neurotransmitter release in the cerebellum through the activation of the extracellular signal-regulated kinases pathway.

Original languageEnglish
Pages (from-to)3601-3606
Number of pages6
JournalNeuroReport
Volume9
Issue number16
Publication statusPublished - Nov 16 1998

Keywords

  • Cerebellar excitatory post synaptic currents
  • Cerebellar granules
  • Cerebellar slices
  • Chemokines
  • Extracellular signal-regulated kinases

ASJC Scopus subject areas

  • Neuroscience(all)

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