Modulation of voltage-dependent calcium channels by glutamate in rat cerebellar granule cells in culture

Olga Zegarra-Moran, Oscar Moran

Research output: Contribution to journalArticlepeer-review

Abstract

Voltage-dependent calcium channels of cerebellar granule cells maintained in a Ca2+-free depolarising solution were recorded using the cell-attached configuration of the patch-clamp technique. An increase in the maximum open probability of calcium channels and a shift in their activation curve toward more hyperpolarising potentials were found in the presence of glutamate, a natural, excitatory amino acid. Such an increase in the activity of calcium channels was not due to ionic fluxes activated by glutamate, and was probably produced by a second messenger pathway triggered by the binding of glutamate to its receptor.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalExperimental Brain Research
Volume95
Issue number1
DOIs
Publication statusPublished - Jul 1993

Keywords

  • Calcium channels
  • Cerebellar granule cells
  • Glutamate
  • Patch clamp
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Modulation of voltage-dependent calcium channels by glutamate in rat cerebellar granule cells in culture'. Together they form a unique fingerprint.

Cite this