Modulation of WHSC2 expression in human endothelial cells

M. Mariotti, M. Manganini, J. A M Maier

Research output: Contribution to journalArticlepeer-review

Abstract

WHSC2, a novel gene recently isolated within the critical region of Wolf-Hirschhorn syndrome, is expressed in endothelial cells. WHSC2 is downregulated by HIV-1 Tat, whereas it is not modulated by angiogenic and pro-differentiative molecules. WHSC2 encodes a basic polypeptide of 528 amino acids. The in vitro translated protein shows a molecular weight of 57 kDa. WHSC2 has two nuclear translocation sequences which actively mediate its transport to the nucleus, as shown in whsc2-GFP-transfected NIH-3T3. We also found a helix-loop-helix (HLH) motif in region 130-185. Since members of the HLH family control differentiation and cell cycle progression, we hypothesize that WHSC2 may function as a transcriptional repressor.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalFEBS Letters
Volume487
Issue number2
DOIs
Publication statusPublished - Dec 29 2000

Keywords

  • Angiogenesis
  • Endothelial cell
  • HIV-1 Tat
  • WHSC2

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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