Abstract
Background and Objective. T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic T-cell non-Hodgkin's lymphoma (T-NHL) are closely related disorders, and distinguishing between the two may be difficult. Cytogenetic investigations of large NHL series reported different recurring chromosomal alterations. Among these, aberrations of chromosome 1p seem to be associated with T-cell differentiation, the region most frequently involved in breakpoints being band 1p32-36. Deletions and translocations involving the same chromosomal region are frequently observed in T-ALL, in which one of the most common genetic changes is the breakage of the TAL1 gene, mapped to the 1p32 chromosomal region. The objective of this study was to assess the possibility of TAL1 involvement also in T-NHL. Design and Methods. A series of 17 pediatric T-NHL patients was molecularly characterized by microsatellite markers analysis and by TAL1 gene microdeletions. Results. TAL1 gene rearrangement was found in one case, while loss of heterozygosity (LOH) and microsatellite instability (MI) was identified in another case. Interpretation and Conclusions. Overall our findings indicate that, differently from T-ALL, neither TAL1 gene involvement nor LOH or MI at 1p32 appear particularly relevant in the oncogenic process of T-NHL transformation.
| Original language | English |
|---|---|
| Pages (from-to) | 110-113 |
| Number of pages | 4 |
| Journal | Haematologica |
| Volume | 84 |
| Issue number | 2 |
| Publication status | Published - Feb 1999 |
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Keywords
- Childhood tumors
- Genetics
- Loss of heterozygosity
- Non-Hodgkin's lymphoma
- TAL1
ASJC Scopus subject areas
- Hematology
Cite this
Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma. / Perotti, Daniela; Pettenella, Francesca; Luksch, Roberto; Giardini, Roberto; Gambirasio, Felicita; Ferrari, Daniela; Fossati-Bellani, Franca; Biondi, Andrea.
In: Haematologica, Vol. 84, No. 2, 02.1999, p. 110-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma
AU - Perotti, Daniela
AU - Pettenella, Francesca
AU - Luksch, Roberto
AU - Giardini, Roberto
AU - Gambirasio, Felicita
AU - Ferrari, Daniela
AU - Fossati-Bellani, Franca
AU - Biondi, Andrea
PY - 1999/2
Y1 - 1999/2
N2 - Background and Objective. T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic T-cell non-Hodgkin's lymphoma (T-NHL) are closely related disorders, and distinguishing between the two may be difficult. Cytogenetic investigations of large NHL series reported different recurring chromosomal alterations. Among these, aberrations of chromosome 1p seem to be associated with T-cell differentiation, the region most frequently involved in breakpoints being band 1p32-36. Deletions and translocations involving the same chromosomal region are frequently observed in T-ALL, in which one of the most common genetic changes is the breakage of the TAL1 gene, mapped to the 1p32 chromosomal region. The objective of this study was to assess the possibility of TAL1 involvement also in T-NHL. Design and Methods. A series of 17 pediatric T-NHL patients was molecularly characterized by microsatellite markers analysis and by TAL1 gene microdeletions. Results. TAL1 gene rearrangement was found in one case, while loss of heterozygosity (LOH) and microsatellite instability (MI) was identified in another case. Interpretation and Conclusions. Overall our findings indicate that, differently from T-ALL, neither TAL1 gene involvement nor LOH or MI at 1p32 appear particularly relevant in the oncogenic process of T-NHL transformation.
AB - Background and Objective. T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic T-cell non-Hodgkin's lymphoma (T-NHL) are closely related disorders, and distinguishing between the two may be difficult. Cytogenetic investigations of large NHL series reported different recurring chromosomal alterations. Among these, aberrations of chromosome 1p seem to be associated with T-cell differentiation, the region most frequently involved in breakpoints being band 1p32-36. Deletions and translocations involving the same chromosomal region are frequently observed in T-ALL, in which one of the most common genetic changes is the breakage of the TAL1 gene, mapped to the 1p32 chromosomal region. The objective of this study was to assess the possibility of TAL1 involvement also in T-NHL. Design and Methods. A series of 17 pediatric T-NHL patients was molecularly characterized by microsatellite markers analysis and by TAL1 gene microdeletions. Results. TAL1 gene rearrangement was found in one case, while loss of heterozygosity (LOH) and microsatellite instability (MI) was identified in another case. Interpretation and Conclusions. Overall our findings indicate that, differently from T-ALL, neither TAL1 gene involvement nor LOH or MI at 1p32 appear particularly relevant in the oncogenic process of T-NHL transformation.
KW - Childhood tumors
KW - Genetics
KW - Loss of heterozygosity
KW - Non-Hodgkin's lymphoma
KW - TAL1
UR - http://www.scopus.com/inward/record.url?scp=0032880197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032880197&partnerID=8YFLogxK
M3 - Article
C2 - 10091407
AN - SCOPUS:0032880197
VL - 84
SP - 110
EP - 113
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 2
ER -