Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma

Daniela Perotti, Francesca Pettenella, Roberto Luksch, Roberto Giardini, Felicita Gambirasio, Daniela Ferrari, Franca Fossati-Bellani, Andrea Biondi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and Objective. T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic T-cell non-Hodgkin's lymphoma (T-NHL) are closely related disorders, and distinguishing between the two may be difficult. Cytogenetic investigations of large NHL series reported different recurring chromosomal alterations. Among these, aberrations of chromosome 1p seem to be associated with T-cell differentiation, the region most frequently involved in breakpoints being band 1p32-36. Deletions and translocations involving the same chromosomal region are frequently observed in T-ALL, in which one of the most common genetic changes is the breakage of the TAL1 gene, mapped to the 1p32 chromosomal region. The objective of this study was to assess the possibility of TAL1 involvement also in T-NHL. Design and Methods. A series of 17 pediatric T-NHL patients was molecularly characterized by microsatellite markers analysis and by TAL1 gene microdeletions. Results. TAL1 gene rearrangement was found in one case, while loss of heterozygosity (LOH) and microsatellite instability (MI) was identified in another case. Interpretation and Conclusions. Overall our findings indicate that, differently from T-ALL, neither TAL1 gene involvement nor LOH or MI at 1p32 appear particularly relevant in the oncogenic process of T-NHL transformation.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalHaematologica
Volume84
Issue number2
Publication statusPublished - Feb 1999

Fingerprint

T-Cell Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Non-Hodgkin's Lymphoma
Pediatrics
Microsatellite Instability
Loss of Heterozygosity
Genes
Gene Rearrangement
Cytogenetics
Chromosome Aberrations
Microsatellite Repeats
Cell Differentiation
T-Lymphocytes

Keywords

  • Childhood tumors
  • Genetics
  • Loss of heterozygosity
  • Non-Hodgkin's lymphoma
  • TAL1

ASJC Scopus subject areas

  • Hematology

Cite this

Perotti, D., Pettenella, F., Luksch, R., Giardini, R., Gambirasio, F., Ferrari, D., ... Biondi, A. (1999). Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma. Haematologica, 84(2), 110-113.

Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma. / Perotti, Daniela; Pettenella, Francesca; Luksch, Roberto; Giardini, Roberto; Gambirasio, Felicita; Ferrari, Daniela; Fossati-Bellani, Franca; Biondi, Andrea.

In: Haematologica, Vol. 84, No. 2, 02.1999, p. 110-113.

Research output: Contribution to journalArticle

Perotti, D, Pettenella, F, Luksch, R, Giardini, R, Gambirasio, F, Ferrari, D, Fossati-Bellani, F & Biondi, A 1999, 'Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma', Haematologica, vol. 84, no. 2, pp. 110-113.
Perotti D, Pettenella F, Luksch R, Giardini R, Gambirasio F, Ferrari D et al. Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma. Haematologica. 1999 Feb;84(2):110-113.
Perotti, Daniela ; Pettenella, Francesca ; Luksch, Roberto ; Giardini, Roberto ; Gambirasio, Felicita ; Ferrari, Daniela ; Fossati-Bellani, Franca ; Biondi, Andrea. / Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma. In: Haematologica. 1999 ; Vol. 84, No. 2. pp. 110-113.
@article{27575f0b6db44b89ba0ab96974e0c894,
title = "Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma",
abstract = "Background and Objective. T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic T-cell non-Hodgkin's lymphoma (T-NHL) are closely related disorders, and distinguishing between the two may be difficult. Cytogenetic investigations of large NHL series reported different recurring chromosomal alterations. Among these, aberrations of chromosome 1p seem to be associated with T-cell differentiation, the region most frequently involved in breakpoints being band 1p32-36. Deletions and translocations involving the same chromosomal region are frequently observed in T-ALL, in which one of the most common genetic changes is the breakage of the TAL1 gene, mapped to the 1p32 chromosomal region. The objective of this study was to assess the possibility of TAL1 involvement also in T-NHL. Design and Methods. A series of 17 pediatric T-NHL patients was molecularly characterized by microsatellite markers analysis and by TAL1 gene microdeletions. Results. TAL1 gene rearrangement was found in one case, while loss of heterozygosity (LOH) and microsatellite instability (MI) was identified in another case. Interpretation and Conclusions. Overall our findings indicate that, differently from T-ALL, neither TAL1 gene involvement nor LOH or MI at 1p32 appear particularly relevant in the oncogenic process of T-NHL transformation.",
keywords = "Childhood tumors, Genetics, Loss of heterozygosity, Non-Hodgkin's lymphoma, TAL1",
author = "Daniela Perotti and Francesca Pettenella and Roberto Luksch and Roberto Giardini and Felicita Gambirasio and Daniela Ferrari and Franca Fossati-Bellani and Andrea Biondi",
year = "1999",
month = "2",
language = "English",
volume = "84",
pages = "110--113",
journal = "Haematologica",
issn = "0390-6078",
publisher = "NLM (Medline)",
number = "2",

}

TY - JOUR

T1 - Molecular analysis of 1p32 genetic involvement in pediatric T-cell non- Hodgkin's lymphoma

AU - Perotti, Daniela

AU - Pettenella, Francesca

AU - Luksch, Roberto

AU - Giardini, Roberto

AU - Gambirasio, Felicita

AU - Ferrari, Daniela

AU - Fossati-Bellani, Franca

AU - Biondi, Andrea

PY - 1999/2

Y1 - 1999/2

N2 - Background and Objective. T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic T-cell non-Hodgkin's lymphoma (T-NHL) are closely related disorders, and distinguishing between the two may be difficult. Cytogenetic investigations of large NHL series reported different recurring chromosomal alterations. Among these, aberrations of chromosome 1p seem to be associated with T-cell differentiation, the region most frequently involved in breakpoints being band 1p32-36. Deletions and translocations involving the same chromosomal region are frequently observed in T-ALL, in which one of the most common genetic changes is the breakage of the TAL1 gene, mapped to the 1p32 chromosomal region. The objective of this study was to assess the possibility of TAL1 involvement also in T-NHL. Design and Methods. A series of 17 pediatric T-NHL patients was molecularly characterized by microsatellite markers analysis and by TAL1 gene microdeletions. Results. TAL1 gene rearrangement was found in one case, while loss of heterozygosity (LOH) and microsatellite instability (MI) was identified in another case. Interpretation and Conclusions. Overall our findings indicate that, differently from T-ALL, neither TAL1 gene involvement nor LOH or MI at 1p32 appear particularly relevant in the oncogenic process of T-NHL transformation.

AB - Background and Objective. T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic T-cell non-Hodgkin's lymphoma (T-NHL) are closely related disorders, and distinguishing between the two may be difficult. Cytogenetic investigations of large NHL series reported different recurring chromosomal alterations. Among these, aberrations of chromosome 1p seem to be associated with T-cell differentiation, the region most frequently involved in breakpoints being band 1p32-36. Deletions and translocations involving the same chromosomal region are frequently observed in T-ALL, in which one of the most common genetic changes is the breakage of the TAL1 gene, mapped to the 1p32 chromosomal region. The objective of this study was to assess the possibility of TAL1 involvement also in T-NHL. Design and Methods. A series of 17 pediatric T-NHL patients was molecularly characterized by microsatellite markers analysis and by TAL1 gene microdeletions. Results. TAL1 gene rearrangement was found in one case, while loss of heterozygosity (LOH) and microsatellite instability (MI) was identified in another case. Interpretation and Conclusions. Overall our findings indicate that, differently from T-ALL, neither TAL1 gene involvement nor LOH or MI at 1p32 appear particularly relevant in the oncogenic process of T-NHL transformation.

KW - Childhood tumors

KW - Genetics

KW - Loss of heterozygosity

KW - Non-Hodgkin's lymphoma

KW - TAL1

UR - http://www.scopus.com/inward/record.url?scp=0032880197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032880197&partnerID=8YFLogxK

M3 - Article

C2 - 10091407

AN - SCOPUS:0032880197

VL - 84

SP - 110

EP - 113

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 2

ER -