Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis

Daniela Capello, Maurizio Martini, Annunziata Gloghini, Michaela Cerri, Silvia Rasi, Clara Deambrogi, Davide Rossi, Michele Spina, Umberto Tirelli, Luigi Maria Larocca, Antonino Carbone, Gianluca Gaidano

Research output: Contribution to journalArticle

Abstract

Background: Human immunodeficiency virus (HIV)-related non-Hodgkin's lymphomas (HIV-NHL) are heterogeneous and associated with distinct molecular pathways. Analysis of immunoglobulin variable genes (IGV) may provide insights into the pathogenesis and histogenesis of HIV-NHL. Design and Methods: IGV rearrangements were amplified from genomic DNA by polymerase chain reaction and directly sequenced in 87 cases of HIV-NHL (17 Burkitt/Burkitt-like lymphomas, 38 diffuse large B-cell lymphomas, and 32 primary central nervous system lymphomas). Results: A skewed IGHV repertoire in specific HIV-NHL clinico-pathological categories was observed. Systemic HIV-diffuse large B-cell lymphomas displayed underrepresentation of the IGHV3 family (11/38, 28.9%; p=0.0047) and, in particular, of the IGHV3-23 gene (0/38; p

Original languageEnglish
Pages (from-to)1178-1185
Number of pages8
JournalHaematologica
Volume93
Issue number8
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Histogenesis
  • HIV
  • Immunoglobulin genes
  • Lymphoma
  • Pathogenesis

ASJC Scopus subject areas

  • Hematology

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