By use of RT-PCR of PML/RARα, we evaluated bone marrow aspirates in 10 patients with APL in long-term disease-free status after induction chemotherapy and consolidation (median 54 months; range 33-101 months from complete remission). All patients were in clinical and cytogenetic remission at the time of molecular evaluation (range 32-96 months from CR). All patients but one were found to be RT-PCR negative at the molecular level for the expression of PML-RARα transcript, confirming that the majority of the patients with long-term survival of APL are characterized by the eradication of the neoplastic clone.
|Number of pages||3|
|Journal||British Journal of Haematology|
|Publication status||Published - 1995|
- acute promyelocytic leukaemia
- minimal residual disease
- PML-RAR-alpha rearrangement
ASJC Scopus subject areas