Molecular and cellular biology of rhabdomyosarcoma

Carla De Giovanni, Lorena Landuzzi, Giordano Nicoletti, Pier Luigi Lollini, Patrizia Nanni

Research output: Contribution to journalArticlepeer-review

Abstract

Rhabdomyosarcoma is a group of soft-tissue sarcomas that share features of skeletal myogenesis, but show extensive heterogeneity in histology, age and site of onset, and prognosis. This review matches recent molecular data with biological features of rhabdomyosarcoma. Alterations in molecular pathways, animal models, cell of origin and potential new therapeutic targets are discussed.

Original languageEnglish
Pages (from-to)1449-1475
Number of pages27
JournalFuture Oncology
Volume5
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • Animal models
  • Gene-expression profiling
  • IGF
  • p53
  • PAX-FKHR
  • Rhabdomyosarcoma
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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