Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

Nadiia Bilous, Riccardo Bomben, Michele Dal Bo, Daniela Capello, Francesco Forconi, Luca Laurenti, Francesco Bertoni, Dimitar G. Efremov, Roberto Marasca, Giovanni Del Poeta, Zoya Martina, Iryna Kryachouk, Iryna Dyagil, Gianluca Gaidano, Anatoliy Chumak, Valter Gattei, Iryna Abramenko

Research output: Contribution to journalArticlepeer-review

Abstract

A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.

Original languageEnglish
Pages (from-to)822-838
Number of pages17
JournalLeukemia and Lymphoma
Volume51
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • Chronic lymphocytic leukemia
  • IGHV genes
  • Stereotyped B-cell receptor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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