Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size

Sabrina Rossi, Daniela Gasparotto, Luisa Toffolatti, Chiara Pastrello, Giovanna Gallina, Alessandra Marzotto, Chiara Sartor, Mattia Barbareschi, Chiara Cantaloni, Luca Messerini, Italo Bearzi, Giannantonio Arrigoni, Guido Mazzoleni, Jonathan A. Fletcher, Paolo G. Casali, Renato Talamini, Roberta Maestro, Angelo Paolo Dei Tos

Research output: Contribution to journalArticle

Abstract

Although Gastrointestinal stromal tumors (GISTs) affect about 0.0014% of the population, GISTs smaller than 1cm (microGISTs) are detectable in about 20% to 30% of elderly individuals. This suggests that microGISTs likely represent premalignant precursors that evolve only in a minute fraction of cases toward overt GISTs. We sought histopathologic and molecular explanations for the infrequent clinical progression in small GISTs. To investigate the mechanisms of GIST progression and identify subsets with differential malignant potential, we carried out a thorough characterization of 170 GISTs

Original languageEnglish
Pages (from-to)1480-1491
Number of pages12
JournalAmerican Journal of Surgical Pathology
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 2010

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Keywords

  • microGISTs
  • novel KIT/PDGFRA mutations
  • small GISTs

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

Rossi, S., Gasparotto, D., Toffolatti, L., Pastrello, C., Gallina, G., Marzotto, A., Sartor, C., Barbareschi, M., Cantaloni, C., Messerini, L., Bearzi, I., Arrigoni, G., Mazzoleni, G., Fletcher, J. A., Casali, P. G., Talamini, R., Maestro, R., & Dei Tos, A. P. (2010). Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size. American Journal of Surgical Pathology, 34(10), 1480-1491. https://doi.org/10.1097/PAS.0b013e3181ef7431