Molecular and cytogenetic remission in a case of subtype M4E acute myelogenous leukemia with minimal monochemotherapy: High sensitivity or spontaneous remission?

Maria Paola Martelli, Roberto Latagliata, Antonio Spadea, Giuseppe Avvisati, Marco Mancini, Atelda Romano, Giovanni Luzi, Maria Concetta Petti

Research output: Contribution to journalArticle

Abstract

Complete remission was observed in an adult patient with acute myelogenous leukemia after minimal monochemotherapy. Remission occurred after a severe febrile pneumonia and was accompanied by cytogenetic and molecular remission. The hypothesis of spontaneous remission was raised, even if a high sensitivity to low-dose cytostatics cannot be excluded. Such spontaneous complete remissions, often associated with bacterial infections and blood transfusions, are extremely rare, and are usually of short duration. Previous cases are summarized, and the role of etiologic factors is discussed.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalEuropean Journal of Haematology
Volume65
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Acute myelogenous leukemia
  • Spontaneous remission

ASJC Scopus subject areas

  • Hematology

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