Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali: L'esempio del "seveso molecular epidemiology project"

Translated title of the contribution: Molecular and genetic methods for studying the effects of occupational and environmental agents: The seveso molecular epidemiology project

A. Baccarelli, A. Pesatori, D. Consonni, D. Patterson, M. Bonzini, B. Marinelli, J. A. Grassman, P. A. Bertazzi, M. T. Landi

Research output: Contribution to journalArticle

Abstract

In 1997, IARC classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as carcinogenic to humans, based on sufficient evidence from animal data and limited evidence from human data. A key role in the IARC classification was played by the well-defined mechanism of TCDD action involving the activation of the Arylhydrocarbon Receptor (AhR). Experimental animal and in-vitro studies indicate that AhR levels decrease following TCDD binding. Nearly 20 years after the Seveso accident, we found a decrease in AhR mRNA levels in TCDD-exposed subjects. AhR transcript levels were correlated with plasma TCDD concentrations. Our results may reflect a down-regulation of AhR, similar to that observed in most receptorial systems. We demonstrated, for the first time in humans, that TCDD-related regulation of the AhR pathway, previously observed in experimental studies, may also occur in exposed subjects. Our data are important for extrapolating AhR-mediated effects from experimental models to humans.

Original languageItalian
Pages (from-to)22-23
Number of pages2
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume26
Issue number4 SUPPL.
Publication statusPublished - 2004

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Molecular Epidemiology
Molecular Biology
Accidents
Polychlorinated Dibenzodioxins
Theoretical Models
Down-Regulation
Messenger RNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

Cite this

Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali : L'esempio del "seveso molecular epidemiology project". / Baccarelli, A.; Pesatori, A.; Consonni, D.; Patterson, D.; Bonzini, M.; Marinelli, B.; Grassman, J. A.; Bertazzi, P. A.; Landi, M. T.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 26, No. 4 SUPPL., 2004, p. 22-23.

Research output: Contribution to journalArticle

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