Molecular and immunological characterization of Staphylococcus aureus in pediatric atopic dermatitis

Implications for prophylaxis and clinical management

Chiara Pascolini, Jolinda Sinagra, Simone Pecetta, Valentina Bordignon, Alessandra De Santis, Laura Cilli, Viviana Cafiso, Grazia Prignano, Bruno Capitanio, Claudio Passariello, Stefania Stefani, Paola Cordiali-Fei, Fabrizio Ensoli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

S. aureus represents a critical cofactor in atopic dermatitis (AD). In this paper, the prevalence of S. aureus infection/colonization was evaluated in 117 children as well as in their cohabitants, in order to assess the value of S. aureus characterization in predicting disease onset and severity and in providing indications for prophylaxis. Results showed that children with AD as well as their cohabitants had a significantly greater incidence of S. aureus infection/colonization as compared to controls. The genetic characterization showed a virtual identity of the bacteria strains collected at different sites of the patients with those found in the cohabitants, suggesting both a direct transmission between the nasal reservoir and the lesions in the same atopic subject and a risk for reinfection within family cohabitants. These data stress the need of preliminary laboratory assessment and posttherapy control in both AD patients and their close contacts for effective S. aureus eradication.

Original languageEnglish
Article number718708
JournalClinical and Developmental Immunology
Volume2011
DOIs
Publication statusPublished - 2011

Fingerprint

Atopic Dermatitis
Staphylococcus aureus
Pediatrics
Infection
Nose
Bacteria
Incidence

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Molecular and immunological characterization of Staphylococcus aureus in pediatric atopic dermatitis : Implications for prophylaxis and clinical management. / Pascolini, Chiara; Sinagra, Jolinda; Pecetta, Simone; Bordignon, Valentina; De Santis, Alessandra; Cilli, Laura; Cafiso, Viviana; Prignano, Grazia; Capitanio, Bruno; Passariello, Claudio; Stefani, Stefania; Cordiali-Fei, Paola; Ensoli, Fabrizio.

In: Clinical and Developmental Immunology, Vol. 2011, 718708, 2011.

Research output: Contribution to journalArticle

Pascolini, Chiara ; Sinagra, Jolinda ; Pecetta, Simone ; Bordignon, Valentina ; De Santis, Alessandra ; Cilli, Laura ; Cafiso, Viviana ; Prignano, Grazia ; Capitanio, Bruno ; Passariello, Claudio ; Stefani, Stefania ; Cordiali-Fei, Paola ; Ensoli, Fabrizio. / Molecular and immunological characterization of Staphylococcus aureus in pediatric atopic dermatitis : Implications for prophylaxis and clinical management. In: Clinical and Developmental Immunology. 2011 ; Vol. 2011.
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AU - Pecetta, Simone

AU - Bordignon, Valentina

AU - De Santis, Alessandra

AU - Cilli, Laura

AU - Cafiso, Viviana

AU - Prignano, Grazia

AU - Capitanio, Bruno

AU - Passariello, Claudio

AU - Stefani, Stefania

AU - Cordiali-Fei, Paola

AU - Ensoli, Fabrizio

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