Molecular aspects of membrane fission in the secretory pathway

D. Corda, C. Hidalgo Carcedo, M. Bonazzi, A. Luini, S. Spanò

Research output: Contribution to journalArticlepeer-review


Membrane fission is essential in various intracellular dissociative transport steps. The molecular mechanisms by which endocytic vesicles detach from the plasma membrane are being rapidly elucidated. Much less is known about the fission mechanisms operating at Golgi tubular networks; these include the Golgi transport and sorting stations, the trans-Golgi and cis-Golgi networks, where the geometry and physical properties of the membranes differ from those at the cell surface. Here we discuss the lipid and protein machineries that have so far been related to the fission process, with emphasis on those acting in the Golgi complex.

Original languageEnglish
Pages (from-to)1819-1832
Number of pages14
JournalCellular and Molecular Life Sciences
Issue number11
Publication statusPublished - Nov 1 2002


  • Acyl-CoA
  • Acyl-transferase
  • CtBP3/BARS
  • Golgi complex
  • Membrane traffic
  • Phosphatidic acid
  • Phospholipase D
  • PITP
  • Protein kinase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology


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