Molecular aspects of the endocrine tumours of the pancreas and the gastrointestinal tract

G. Rindi, M. E. Candusso, E. Solcia

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Neuroendocrine tumours of the gastroenteropancreatic tract are growths originating either from the cells of the diffuse (neuro)endocrine system, such as gastric carcinoids and islet cell tumours, or from nerve structures, such as duodenal paragangliomas. A great deal of cellular and clinical information is available whereas data concerning the genetic and molecular basis of diffuse (neuro)endocrine system tumours of the gastroenteropancreatic tract are very few and fragmentary. The present paper reviews some genetic and molecular investigations of potential interest. As far as concerns the genetic background of diffuse (neuro)endocrine system tumours, the frequent loss of heterozygosity for the locus of Multiple Endocrine Neoplasia type 1 in tumour samples suggests a potential role of the Multiple Endocrine Neoplasia gene. With regard to the molecular background, no mutation of the p53 or retinoblastoma susceptibility (Rb) genes has been demonstrated. Useful data have been generated by in situ analysis of the proliferation activity of tumours.

Original languageEnglish
JournalItalian Journal of Gastroenterology and Hepatology
Volume31
Issue numberSUPPL. 2
Publication statusPublished - 1999

Fingerprint

Islets of Langerhans
Endocrine System
Gastrointestinal Tract
Molecular Biology
Neoplasms
Multiple Endocrine Neoplasia
Islet Cell Adenoma
Retinoblastoma Genes
Multiple Endocrine Neoplasia Type 1
Paraganglioma
Retinoblastoma
Loss of Heterozygosity
Carcinoid Tumor
Stomach
Mutation
Growth
Genes

Keywords

  • Ki67
  • Loss of heterozygosity
  • MEN-1 gene
  • Neuroendocrine tumours
  • p53
  • Retinoblastoma gene

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Molecular aspects of the endocrine tumours of the pancreas and the gastrointestinal tract. / Rindi, G.; Candusso, M. E.; Solcia, E.

In: Italian Journal of Gastroenterology and Hepatology, Vol. 31, No. SUPPL. 2, 1999.

Research output: Contribution to journalArticle

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