Molecular bases of circadian rhythmicity in renal physiology and pathology

Olivier Bonny, Manlio Vinciguerra, Michelle L. Gumz, Gianluigi Mazzoccoli

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nychthemeral changes of sodium sensitivity, physical activity, vascular tone, autonomic function and neurotransmitter release from sympathetic innervations. The circadian rhythmicity of body physiology is driven by central and peripheral biological clockworks and entrained by the geophysical light/dark cycle. Chronodisruption, defined as the mismatch between environmental-social cues and physiological-behavioral patterns, causes internal desynchronization of periodic functions, leading to pathophysiological mechanisms underlying degenerative, immune related, metabolic and neoplastic diseases. In this review we will address the genetic, molecular and anatomical elements that hardwire circadian rhythmicity in renal physiology and subtend disarray of time-dependent changes in renal pathology.

Original languageEnglish
Pages (from-to)2421-2431
Number of pages11
JournalNephrology Dialysis Transplantation
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Periodicity
Pathology
Kidney
Physiological Phenomena
Acid-Base Equilibrium
Metabolic Diseases
Photoperiod
Cues
Neurotransmitter Agents
Blood Vessels
Molecular Biology
Homeostasis
Sodium
Hormones
Blood Pressure

Keywords

  • circadian
  • clock gene
  • kidney

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Molecular bases of circadian rhythmicity in renal physiology and pathology. / Bonny, Olivier; Vinciguerra, Manlio; Gumz, Michelle L.; Mazzoccoli, Gianluigi.

In: Nephrology Dialysis Transplantation, Vol. 28, No. 10, 10.2013, p. 2421-2431.

Research output: Contribution to journalArticle

Bonny, Olivier ; Vinciguerra, Manlio ; Gumz, Michelle L. ; Mazzoccoli, Gianluigi. / Molecular bases of circadian rhythmicity in renal physiology and pathology. In: Nephrology Dialysis Transplantation. 2013 ; Vol. 28, No. 10. pp. 2421-2431.
@article{fb2a063a4fa941c7b0ade5a4b0a13362,
title = "Molecular bases of circadian rhythmicity in renal physiology and pathology",
abstract = "The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nychthemeral changes of sodium sensitivity, physical activity, vascular tone, autonomic function and neurotransmitter release from sympathetic innervations. The circadian rhythmicity of body physiology is driven by central and peripheral biological clockworks and entrained by the geophysical light/dark cycle. Chronodisruption, defined as the mismatch between environmental-social cues and physiological-behavioral patterns, causes internal desynchronization of periodic functions, leading to pathophysiological mechanisms underlying degenerative, immune related, metabolic and neoplastic diseases. In this review we will address the genetic, molecular and anatomical elements that hardwire circadian rhythmicity in renal physiology and subtend disarray of time-dependent changes in renal pathology.",
keywords = "circadian, clock gene, kidney",
author = "Olivier Bonny and Manlio Vinciguerra and Gumz, {Michelle L.} and Gianluigi Mazzoccoli",
year = "2013",
month = "10",
doi = "10.1093/ndt/gft319",
language = "English",
volume = "28",
pages = "2421--2431",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Molecular bases of circadian rhythmicity in renal physiology and pathology

AU - Bonny, Olivier

AU - Vinciguerra, Manlio

AU - Gumz, Michelle L.

AU - Mazzoccoli, Gianluigi

PY - 2013/10

Y1 - 2013/10

N2 - The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nychthemeral changes of sodium sensitivity, physical activity, vascular tone, autonomic function and neurotransmitter release from sympathetic innervations. The circadian rhythmicity of body physiology is driven by central and peripheral biological clockworks and entrained by the geophysical light/dark cycle. Chronodisruption, defined as the mismatch between environmental-social cues and physiological-behavioral patterns, causes internal desynchronization of periodic functions, leading to pathophysiological mechanisms underlying degenerative, immune related, metabolic and neoplastic diseases. In this review we will address the genetic, molecular and anatomical elements that hardwire circadian rhythmicity in renal physiology and subtend disarray of time-dependent changes in renal pathology.

AB - The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nychthemeral changes of sodium sensitivity, physical activity, vascular tone, autonomic function and neurotransmitter release from sympathetic innervations. The circadian rhythmicity of body physiology is driven by central and peripheral biological clockworks and entrained by the geophysical light/dark cycle. Chronodisruption, defined as the mismatch between environmental-social cues and physiological-behavioral patterns, causes internal desynchronization of periodic functions, leading to pathophysiological mechanisms underlying degenerative, immune related, metabolic and neoplastic diseases. In this review we will address the genetic, molecular and anatomical elements that hardwire circadian rhythmicity in renal physiology and subtend disarray of time-dependent changes in renal pathology.

KW - circadian

KW - clock gene

KW - kidney

UR - http://www.scopus.com/inward/record.url?scp=84884958331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884958331&partnerID=8YFLogxK

U2 - 10.1093/ndt/gft319

DO - 10.1093/ndt/gft319

M3 - Article

VL - 28

SP - 2421

EP - 2431

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 10

ER -