Dendritic cells (DC) are antigen presenting cells (APC) able to activate naive T lymphocytes. Immature DC are very motile cells and localize in non lymphoid organs where they exert a sentinel function for incoming Ag. Upon exposure to immune or inflammatory signals DC undergo maturation and migrate to T cell areas of lymphoid organs. Thus, the correct functioning of DC involves localization in tissues and trafficking via the lymph or blood to lymphoid organs. Chemokines have emerged as important regulators of DC migration. DC express receptors for and respond to a set of chemoattractants which overlaps with, but is distinct from, that active on other leukocytes. Functional maturation is associated with loss of responsiveness to chemokines present at sites of inflammation (MCP-3, RANTES, MIP-1α, MIP-1β e MIP-3α) and acquisition of a receptor repertoire which renders these cells responsive to signals (SLC, MIP-3β) which guide their localization in lymphoid organs. A better understanding of the molecular basis of DC trafficking may provide molecular and conceptual tools to direct and modulate DC traffic as a strategy to upregulate and orient specific immunity.
|Translated title of the contribution||Molecular bases of dendritic cell migration in vitro and in vivo|
|Number of pages||4|
|Journal||EOS Rivista di Immunologia ed Immunofarmacologia|
|Publication status||Published - 2000|
ASJC Scopus subject areas