Molecular basis of inherited spastic paraplegias

Giorgio Casari, Elena Rugarli

Research output: Contribution to journalArticlepeer-review


Recently, paraplegin and spastin have been found to be mutated in two autosomal forms of hereditary spastic paraplegia. Both proteins harbour a common ATPase domain that expresses a chaperone function. Paraplegin is a nuclear-encoded mitochondrial metalloprotease, while the exact role and subcellular localisation of spastin are still unclear.

Original languageEnglish
Pages (from-to)336-342
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number3
Publication statusPublished - Jun 1 2001

ASJC Scopus subject areas

  • Genetics


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