Molecular basis of inherited spastic paraplegias

Giorgio Casari, Elena Rugarli

Research output: Contribution to journalArticle

Abstract

Recently, paraplegin and spastin have been found to be mutated in two autosomal forms of hereditary spastic paraplegia. Both proteins harbour a common ATPase domain that expresses a chaperone function. Paraplegin is a nuclear-encoded mitochondrial metalloprotease, while the exact role and subcellular localisation of spastin are still unclear.

Original languageEnglish
Pages (from-to)336-342
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume11
Issue number3
DOIs
Publication statusPublished - Jun 1 2001

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ASJC Scopus subject areas

  • Genetics

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