Molecular basis of inherited spastic paraplegias

Giorgio Casari, Elena Rugarli

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Recently, paraplegin and spastin have been found to be mutated in two autosomal forms of hereditary spastic paraplegia. Both proteins harbour a common ATPase domain that expresses a chaperone function. Paraplegin is a nuclear-encoded mitochondrial metalloprotease, while the exact role and subcellular localisation of spastin are still unclear.

Original languageEnglish
Pages (from-to)336-342
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume11
Issue number3
DOIs
Publication statusPublished - Jun 1 2001

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Hereditary Spastic Paraplegia
Paraplegia
Metalloproteases
Adenosine Triphosphatases
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Molecular basis of inherited spastic paraplegias. / Casari, Giorgio; Rugarli, Elena.

In: Current Opinion in Genetics and Development, Vol. 11, No. 3, 01.06.2001, p. 336-342.

Research output: Contribution to journalArticle

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