TY - JOUR
T1 - Molecular changes of malignant mesothelioma in the testis and their impact on prognosis
T2 - Analyses of two cases
AU - Serio, Gabriella
AU - Pagliarulo, Vincenzo
AU - Marzullo, Andrea
AU - Punzi, Alessandra
AU - Pezzuto, Federica
AU - Gentile, Mattia
AU - Pennella, Antonio
AU - Nazzaro, Pietro
AU - Buonadonna, Antonia Lucia
AU - Covelli, Claudia
AU - Lettini, Teresa
AU - Scattone, Anna
PY - 2016
Y1 - 2016
N2 - Malignant mesothelioma is a rare and aggressive tumour, generally asbestos-related. When the tumour arises in the pleura or peritoneum a non-occupational or environmental asbestos exposure has also been reported. The latency period from the initial asbestos exposure to the clinical diagnosis is variable but usually long, sometimes as long as 30-40 years. Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is extremely rare; in Italy, the standardized incidence rate for MMTVT is 0.2 cases per million inhabitants. Usually, in this site the tumour appears to be idiopathic in nature but exceptionally, an asbestos exposure has been documented. Here, we report two patients with locally advanced disease; an occupational history of asbestos exposure was ascertained in one case. Radical surgery was performed and adjuvant chemotherapy was administered only in one case.
AB - Malignant mesothelioma is a rare and aggressive tumour, generally asbestos-related. When the tumour arises in the pleura or peritoneum a non-occupational or environmental asbestos exposure has also been reported. The latency period from the initial asbestos exposure to the clinical diagnosis is variable but usually long, sometimes as long as 30-40 years. Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is extremely rare; in Italy, the standardized incidence rate for MMTVT is 0.2 cases per million inhabitants. Usually, in this site the tumour appears to be idiopathic in nature but exceptionally, an asbestos exposure has been documented. Here, we report two patients with locally advanced disease; an occupational history of asbestos exposure was ascertained in one case. Radical surgery was performed and adjuvant chemotherapy was administered only in one case.
KW - Mesothelioma
KW - Microarray-comparative hybridization
KW - Prognosis
KW - Testis
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M3 - Article
AN - SCOPUS:84994052437
VL - 9
SP - 7658
EP - 7667
JO - International Journal of Clinical and Experimental Pathology
JF - International Journal of Clinical and Experimental Pathology
SN - 1936-2625
IS - 7
ER -