Molecular changes of malignant mesothelioma in the testis and their impact on prognosis: Analyses of two cases

Gabriella Serio, Vincenzo Pagliarulo, Andrea Marzullo, Alessandra Punzi, Federica Pezzuto, Mattia Gentile, Antonio Pennella, Pietro Nazzaro, Antonia Lucia Buonadonna, Claudia Covelli, Teresa Lettini, Anna Scattone

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant mesothelioma is a rare and aggressive tumour, generally asbestos-related. When the tumour arises in the pleura or peritoneum a non-occupational or environmental asbestos exposure has also been reported. The latency period from the initial asbestos exposure to the clinical diagnosis is variable but usually long, sometimes as long as 30-40 years. Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is extremely rare; in Italy, the standardized incidence rate for MMTVT is 0.2 cases per million inhabitants. Usually, in this site the tumour appears to be idiopathic in nature but exceptionally, an asbestos exposure has been documented. Here, we report two patients with locally advanced disease; an occupational history of asbestos exposure was ascertained in one case. Radical surgery was performed and adjuvant chemotherapy was administered only in one case.

Original languageEnglish
Pages (from-to)7658-7667
Number of pages10
JournalInternational Journal of Clinical and Experimental Pathology
Volume9
Issue number7
Publication statusPublished - 2016

Keywords

  • Mesothelioma
  • Microarray-comparative hybridization
  • Prognosis
  • Testis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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