Molecular chaperones as therapeutic targets to counteract proteostasis defects

Monica Cattaneo, Roberto Dominici, Marina Cardano, Giuseppe Diaferia, Ermanna Rovida, Ida Biunno

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The health of cells is preserved by the levels and correct folding states of the proteome, which is generated and maintained by the proteostasis network, an integrated biological system consisting of several cytoprotective and degradative pathways. Indeed, the health conditions of the proteostasis network is a fundamental prerequisite to life as the inability to cope with the mismanagement of protein folding arising from genetic, epigenetic, and micro-environment stress appears to trigger a whole spectrum of unrelated diseases. Here we describe the potential functional role of the proteostasis network in tumor biology and in conformational diseases debating on how the signaling branches of this biological system may be manipulated to develop more efficacious and selective therapeutic strategies. We discuss the dual strategy of these processes in modulating the folding activity of molecular chaperones in order to counteract the antithetic proteostasis deficiencies occurring in cancer and loss/gain of function diseases. Finally, we provide perspectives on how to improve the outcome of these disorders by taking advantage of proteostasis modeling.

Original languageEnglish
Pages (from-to)1226-1234
Number of pages9
JournalJournal of Cellular Physiology
Volume227
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Molecular Chaperones
Biological systems
Defects
Proteostasis Deficiencies
Health
Protein folding
Protein Folding
Proteome
Epigenomics
Tumors
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Molecular chaperones as therapeutic targets to counteract proteostasis defects. / Cattaneo, Monica; Dominici, Roberto; Cardano, Marina; Diaferia, Giuseppe; Rovida, Ermanna; Biunno, Ida.

In: Journal of Cellular Physiology, Vol. 227, No. 3, 03.2012, p. 1226-1234.

Research output: Contribution to journalArticle

Cattaneo, Monica ; Dominici, Roberto ; Cardano, Marina ; Diaferia, Giuseppe ; Rovida, Ermanna ; Biunno, Ida. / Molecular chaperones as therapeutic targets to counteract proteostasis defects. In: Journal of Cellular Physiology. 2012 ; Vol. 227, No. 3. pp. 1226-1234.
@article{8fdb794c473f4d98bab24781006b5740,
title = "Molecular chaperones as therapeutic targets to counteract proteostasis defects",
abstract = "The health of cells is preserved by the levels and correct folding states of the proteome, which is generated and maintained by the proteostasis network, an integrated biological system consisting of several cytoprotective and degradative pathways. Indeed, the health conditions of the proteostasis network is a fundamental prerequisite to life as the inability to cope with the mismanagement of protein folding arising from genetic, epigenetic, and micro-environment stress appears to trigger a whole spectrum of unrelated diseases. Here we describe the potential functional role of the proteostasis network in tumor biology and in conformational diseases debating on how the signaling branches of this biological system may be manipulated to develop more efficacious and selective therapeutic strategies. We discuss the dual strategy of these processes in modulating the folding activity of molecular chaperones in order to counteract the antithetic proteostasis deficiencies occurring in cancer and loss/gain of function diseases. Finally, we provide perspectives on how to improve the outcome of these disorders by taking advantage of proteostasis modeling.",
author = "Monica Cattaneo and Roberto Dominici and Marina Cardano and Giuseppe Diaferia and Ermanna Rovida and Ida Biunno",
year = "2012",
month = "3",
doi = "10.1002/jcp.22856",
language = "English",
volume = "227",
pages = "1226--1234",
journal = "Journal of cellular and comparative physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Molecular chaperones as therapeutic targets to counteract proteostasis defects

AU - Cattaneo, Monica

AU - Dominici, Roberto

AU - Cardano, Marina

AU - Diaferia, Giuseppe

AU - Rovida, Ermanna

AU - Biunno, Ida

PY - 2012/3

Y1 - 2012/3

N2 - The health of cells is preserved by the levels and correct folding states of the proteome, which is generated and maintained by the proteostasis network, an integrated biological system consisting of several cytoprotective and degradative pathways. Indeed, the health conditions of the proteostasis network is a fundamental prerequisite to life as the inability to cope with the mismanagement of protein folding arising from genetic, epigenetic, and micro-environment stress appears to trigger a whole spectrum of unrelated diseases. Here we describe the potential functional role of the proteostasis network in tumor biology and in conformational diseases debating on how the signaling branches of this biological system may be manipulated to develop more efficacious and selective therapeutic strategies. We discuss the dual strategy of these processes in modulating the folding activity of molecular chaperones in order to counteract the antithetic proteostasis deficiencies occurring in cancer and loss/gain of function diseases. Finally, we provide perspectives on how to improve the outcome of these disorders by taking advantage of proteostasis modeling.

AB - The health of cells is preserved by the levels and correct folding states of the proteome, which is generated and maintained by the proteostasis network, an integrated biological system consisting of several cytoprotective and degradative pathways. Indeed, the health conditions of the proteostasis network is a fundamental prerequisite to life as the inability to cope with the mismanagement of protein folding arising from genetic, epigenetic, and micro-environment stress appears to trigger a whole spectrum of unrelated diseases. Here we describe the potential functional role of the proteostasis network in tumor biology and in conformational diseases debating on how the signaling branches of this biological system may be manipulated to develop more efficacious and selective therapeutic strategies. We discuss the dual strategy of these processes in modulating the folding activity of molecular chaperones in order to counteract the antithetic proteostasis deficiencies occurring in cancer and loss/gain of function diseases. Finally, we provide perspectives on how to improve the outcome of these disorders by taking advantage of proteostasis modeling.

UR - http://www.scopus.com/inward/record.url?scp=84155184186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84155184186&partnerID=8YFLogxK

U2 - 10.1002/jcp.22856

DO - 10.1002/jcp.22856

M3 - Article

C2 - 21618531

AN - SCOPUS:84155184186

VL - 227

SP - 1226

EP - 1234

JO - Journal of cellular and comparative physiology

JF - Journal of cellular and comparative physiology

SN - 0021-9541

IS - 3

ER -