Molecular characterization and developmental expression pattern of the chicken apolipoprotein D gene: Implications for the evolution of vertebrate lipocalins

María D. Ganfornina, Diego Sánchez, Aldo Pagano, Laura Tonachini, Fiorella Descalzi-Cancedda, Salvador Martínez

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The insect Lazarillo and the mammalian apolipoprotein D (ApoD) are orthologous members of the lipocalin protein family. We report the cloning and embryonic expression of chicken ApoD, the first molecularly characterized nonmammalian ApoD. We also report the ApoD expression in mouse during postnatal development and some novel aspects of the expression of the paralogous lipocalin prostaglandin D-synthase (PGDS) and discuss these results in view of the lipocalin family evolution in vertebrates. ApoD is expressed in subsets of central nervous system (CNS) neurons and glia during late chicken embryogenesis. Contrary to mouse ApoD, no expression appears in neural crest-derived cephalic mesenchyme and blood vessel pericytes. Also, ApoD is expressed in developing chicken feathers. These expressions are corroborated by quantitative reverse transcriptase-polymerase chain reaction profiles. ApoD is expressed during mouse postnatal development in a subset of CNS neurons, astrocytes and oligodendrocytes, but also in meninges and pericytes. Chicken PGDS is expressed in brain meninges and perivascular cells. Our results suggest that the amniote last common ancestor expressed ApoD and PGDS in the brain during embryogenesis. ApoD appears restricted to ectodermal derivatives, whereas PGDS is expressed by derivatives of the three germ layers.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalDevelopmental Dynamics
Volume232
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Apolipoproteins D
Lipocalins
Vertebrates
Chickens
prostaglandin R2 D-isomerase
Genes
Meninges
Pericytes
Embryonic Development
Central Nervous System
Neurons
Germ Layers
Feathers
Neural Crest
Oligodendroglia
Brain
Mesoderm
Reverse Transcriptase Polymerase Chain Reaction
Neuroglia
Astrocytes

Keywords

  • Calycin
  • Feather development
  • Lipocalin
  • Neural development

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Molecular characterization and developmental expression pattern of the chicken apolipoprotein D gene : Implications for the evolution of vertebrate lipocalins. / Ganfornina, María D.; Sánchez, Diego; Pagano, Aldo; Tonachini, Laura; Descalzi-Cancedda, Fiorella; Martínez, Salvador.

In: Developmental Dynamics, Vol. 232, No. 1, 01.2005, p. 191-199.

Research output: Contribution to journalArticle

Ganfornina, María D. ; Sánchez, Diego ; Pagano, Aldo ; Tonachini, Laura ; Descalzi-Cancedda, Fiorella ; Martínez, Salvador. / Molecular characterization and developmental expression pattern of the chicken apolipoprotein D gene : Implications for the evolution of vertebrate lipocalins. In: Developmental Dynamics. 2005 ; Vol. 232, No. 1. pp. 191-199.
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