Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

A. Ciccodicola; R. Dono; S. Obici; A. Simeone; M. Zollo; M. Graziella Persico

Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

A. Ciccodicola, R. Dono, S. Obici, A. Simeone, M. Zollo, M. Graziella Persico

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Abstract

A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

Original language	English
Pages (from-to)	1987-1991
Number of pages	5
Journal	EMBO Journal
Volume	8
Issue number	7
Publication status	Published - 1989

ASJC Scopus subject areas

Cell Biology
Genetics

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title = "Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells",

abstract = "A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.",

author = "A. Ciccodicola and R. Dono and S. Obici and A. Simeone and M. Zollo and {Graziella Persico}, M.",

year = "1989",

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T1 - Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

AU - Ciccodicola, A.

AU - Dono, R.

AU - Obici, S.

AU - Simeone, A.

AU - Zollo, M.

AU - Graziella Persico, M.

PY - 1989

Y1 - 1989

N2 - A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

AB - A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

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JO - EMBO Journal

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