Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells

A. Ciccodicola, R. Dono, S. Obici, A. Simeone, M. Zollo, M. Graziella Persico

Research output: Contribution to journalArticlepeer-review

Abstract

A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

Original languageEnglish
Pages (from-to)1987-1991
Number of pages5
JournalEMBO Journal
Volume8
Issue number7
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

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