Molecular characterization of rotavirus disclosed the first introduction of G12P[8] strain in northern Italy

Pellegrinelli Laura, Ianiro Giovanni, Pariani Elena, Monini Marina, Ruggeri Franco Maria, Binda Sandro

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: This paper discusses the unexpected findings from the RotaNet-Italy hospital-based surveillance study carried out in northern Italy. Materials & methods: From September 2015 to August 2016, 51 rotavirus-A (RVA) positive fecal samples were collected from children aged less than 15 years, who were hospitalized for acute gastroenteritis in Lombardy, northern Italy. Results: Molecular characterization revealed the predominance of the uncommon G12P[8] RVA strain, which was detected in 49% of cases. Phylogenetic analysis showed that these G12 strains clustered into lineage 3. Conclusion: To our knowledge, this is the first study on the G12P[8] genotype's introduction in northern Italy. Our findings emphasize the importance of the surveillance of RVA gastroenteritis with the aim of obtaining new insight into the unusual newly emerging RVA strains.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalFuture Virology
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

Keywords

  • children
  • G12P[8] genotype
  • rotavirus-A
  • surveillance study

ASJC Scopus subject areas

  • Virology

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