Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

Nicolai Wagtmann, Roberto Biassoni, Claudia Cantoni, Simonetta Verdiani, Mauro S. Malnati, Massimo Vitale, Cristina Bottino, Lorenzo Moretta, Alessandro Moretta, Eric O. Long

Research output: Contribution to journalArticlepeer-review

Abstract

Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Crosslinking of the p58 NK receptor, involved In the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning of the p58 NK receptor reported here revealed a new member of the immunoglobulin superfamily. Five distinct p58 receptors, with sequence diversity in the immunoglobulin-related domains, were Identified in a single individual. All NK clones tested expressed at least one p58 member. Three different types of transmembrane and cytoplasmic domains exist, even among receptors with closely related extracellular domains. These data revealed a repertoire of NK cells with clonally distributed p58 receptors exhibiting diversity in both extracellular and intracellular domains.

Original languageEnglish
Pages (from-to)439-449
Number of pages11
JournalImmunity
Volume2
Issue number5
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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