Molecular Cloning of TER1, a Chemokine Receptor-Like Gene Expressed by Lymphoid Tissues

Monica Napolitano, Alessandra Zingoni, Giovanni Bernardini, Gaia Spinetti, Anna Nista, Clelia T. Storlazzi, Mariano Rocchi, Angela Santoni

Research output: Contribution to journalArticlepeer-review

Abstract

Several chemokine receptors have been cloned and shown to belong to a superfamily of seven transmembrane, G protein-coupled receptors. We report here the molecular cloning of TER1, a novel human chemokine receptor-like gene. The amino acid sequence deduced from the TER1 cDNA shows 43, 40, 40, and 39% identity to CCR4, CCR5, CCR1, and CCR2B β chemokine receptors, respectively. By the use of fluorescent in situ hybridization, we have mapped the TER1 gene to chromosome 3p21, clustered with other chemokine receptor genes. By Northern blot analysis, TER1 mRNA is found to be expressed in the thymus, spleen, and at barely detectable levels in peripheral blood lymphocytes. Moreover, TER1 message is abundant in the NK cell line NK3.3 and in the T cell line MOLT-4. The restricted TER1 expression in cells and tissues of the lymphoid lineage suggests that this receptor may play a role in regulating immune functions.

Original languageEnglish
Pages (from-to)2759-2763
Number of pages5
JournalJournal of Immunology
Volume157
Issue number7
Publication statusPublished - Oct 1 1996

ASJC Scopus subject areas

  • Immunology

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