Molecular Crosstalking among Noncoding RNAs

A New Network Layer of Genome Regulation in Cancer

Marco Ragusa, Cristina Barbagallo, Duilia Brex, Angela Caponnetto, Matilde Cirnigliaro, Rosalia Battaglia, Davide Barbagallo, Cinzia Di Pietro, Michele Purrello

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression. ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs). Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer. Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics. In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.

Original languageEnglish
Article number4723193
JournalInternational Journal of Genomics
Volume2017
DOIs
Publication statusPublished - 2017

Fingerprint

Untranslated RNA
Network layers
Genes
Genome
Neoplasms
RNA
Long Noncoding RNA
Phenotype
Complex networks
Structural integrity
Crosstalk
Eukaryota
MicroRNAs
Proteins
Neoplasm Metastasis
Messenger RNA
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Pharmaceutical Science

Cite this

Ragusa, M., Barbagallo, C., Brex, D., Caponnetto, A., Cirnigliaro, M., Battaglia, R., ... Purrello, M. (2017). Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer. International Journal of Genomics, 2017, [4723193]. https://doi.org/10.1155/2017/4723193

Molecular Crosstalking among Noncoding RNAs : A New Network Layer of Genome Regulation in Cancer. / Ragusa, Marco; Barbagallo, Cristina; Brex, Duilia; Caponnetto, Angela; Cirnigliaro, Matilde; Battaglia, Rosalia; Barbagallo, Davide; Di Pietro, Cinzia; Purrello, Michele.

In: International Journal of Genomics, Vol. 2017, 4723193, 2017.

Research output: Contribution to journalReview article

Ragusa, M, Barbagallo, C, Brex, D, Caponnetto, A, Cirnigliaro, M, Battaglia, R, Barbagallo, D, Di Pietro, C & Purrello, M 2017, 'Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer', International Journal of Genomics, vol. 2017, 4723193. https://doi.org/10.1155/2017/4723193
Ragusa, Marco ; Barbagallo, Cristina ; Brex, Duilia ; Caponnetto, Angela ; Cirnigliaro, Matilde ; Battaglia, Rosalia ; Barbagallo, Davide ; Di Pietro, Cinzia ; Purrello, Michele. / Molecular Crosstalking among Noncoding RNAs : A New Network Layer of Genome Regulation in Cancer. In: International Journal of Genomics. 2017 ; Vol. 2017.
@article{935c5a58bfe84548ac661c69e358e114,
title = "Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer",
abstract = "Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression. ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs). Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer. Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics. In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.",
author = "Marco Ragusa and Cristina Barbagallo and Duilia Brex and Angela Caponnetto and Matilde Cirnigliaro and Rosalia Battaglia and Davide Barbagallo and {Di Pietro}, Cinzia and Michele Purrello",
year = "2017",
doi = "10.1155/2017/4723193",
language = "English",
volume = "2017",
journal = "International Journal of Genomics",
issn = "2314-436X",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Molecular Crosstalking among Noncoding RNAs

T2 - A New Network Layer of Genome Regulation in Cancer

AU - Ragusa, Marco

AU - Barbagallo, Cristina

AU - Brex, Duilia

AU - Caponnetto, Angela

AU - Cirnigliaro, Matilde

AU - Battaglia, Rosalia

AU - Barbagallo, Davide

AU - Di Pietro, Cinzia

AU - Purrello, Michele

PY - 2017

Y1 - 2017

N2 - Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression. ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs). Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer. Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics. In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.

AB - Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression. ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs). Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer. Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics. In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=85031937572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031937572&partnerID=8YFLogxK

U2 - 10.1155/2017/4723193

DO - 10.1155/2017/4723193

M3 - Review article

VL - 2017

JO - International Journal of Genomics

JF - International Journal of Genomics

SN - 2314-436X

M1 - 4723193

ER -