Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis

C. Contini, S. Seraceni, R. Cultrera, M. Castellazzi, E. Granieri, E. Fainardi

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of Chlamydia-like organism DNA was investigated by polymerase chain reaction (PCR) in cerebrospinal fluid (CSF) samples from 27 patients previously found positive for Chlamydia pneumoniae DNA: 12 with multiple sclerosis (MS), grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity, 8 with other inflammatory neurological disorders and 7 with non-inflammatory neurological disorders. PCR evidence of Chlamydia-like organisms in CSF was observed only in two relapsing-remitting MS patients with clinical and MRI disease activity. These findings suggest a possible association between C. pneumoniae and Chlamydia-like organism brain infections as a cofactor in MS development.

Original languageEnglish
Pages (from-to)564-566
Number of pages3
JournalMultiple Sclerosis Journal
Volume14
Issue number4
DOIs
Publication statusPublished - May 2008

Keywords

  • Cerebrospinal fluid
  • Cylamydia-like organisms
  • Multiple sclerosis
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Clinical Neurology

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