Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: A focus on AKT

Marcello Ceci, John Ross, Gianluigi Condorelli

Research output: Contribution to journalArticle

Abstract

Cardiomyocytes (CMCs) adapt to physiological or pathological stimuli by undergoing molecular changes which differentiate according to the specificity of the stimulus and eventually generate a phenotype with peculiar molecular characteristics. Here, we review the literature on the molecular mechanisms activated in the CMC during physiologic adaptation to stress, as opposed to maladaptation. The critical role of the IGF-1 receptor/PI3K/Akt signaling pathway during this process is described, including effector targets regulating inotropism and cell size.

Original languageEnglish
Pages (from-to)905-912
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume37
Issue number5
DOIs
Publication statusPublished - Nov 2004

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Keywords

  • AKT
  • Cardiomyocyte
  • Hypertrophy
  • Inotropism
  • Physiologic adaptation
  • Translation

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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