Abstract
In the analysis of non-Hodgkin's lymphomas (NHL), molecular techniques have become of increasing pratical importance both for diagnostic purposes, at disease onset, and in order to accurately evaluate prognosis, following specific therapies. Moreover, the presence of disease-specific or clonal abnormalities, such as chromosomal translocation, can provide markers for the detection of minimal residual disease (MRD). In this regard, a growing number of largely overlapping techniques including Southern blotting (SB), polymerase chain reaction (PCR) and fluorescent in-situ hybridization (FISH) are responsible for these advances. In view of these novel investigational possibilities, it is of paramount importance to evaluate correctly the specific role of each technique with respect to classical analyses investigating morphology, immunophenotype and karyotype.
| Original language | Italian |
|---|---|
| Pages (from-to) | 21-28 |
| Number of pages | 8 |
| Journal | Impegno Ospedaliero, Sezione Scientifica |
| Volume | 22 |
| Issue number | 5 |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Diagnostica molecolare dei linfomi non-Hodgkin's : Impatto nella diagnosi e valutazione della malattia minima residua. / Gattei, V.; Attadia, V.; Di Francia, R.; Degan, M.
In: Impegno Ospedaliero, Sezione Scientifica, Vol. 22, No. 5, 2001, p. 21-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diagnostica molecolare dei linfomi non-Hodgkin's
T2 - Impatto nella diagnosi e valutazione della malattia minima residua
AU - Gattei, V.
AU - Attadia, V.
AU - Di Francia, R.
AU - Degan, M.
PY - 2001
Y1 - 2001
N2 - In the analysis of non-Hodgkin's lymphomas (NHL), molecular techniques have become of increasing pratical importance both for diagnostic purposes, at disease onset, and in order to accurately evaluate prognosis, following specific therapies. Moreover, the presence of disease-specific or clonal abnormalities, such as chromosomal translocation, can provide markers for the detection of minimal residual disease (MRD). In this regard, a growing number of largely overlapping techniques including Southern blotting (SB), polymerase chain reaction (PCR) and fluorescent in-situ hybridization (FISH) are responsible for these advances. In view of these novel investigational possibilities, it is of paramount importance to evaluate correctly the specific role of each technique with respect to classical analyses investigating morphology, immunophenotype and karyotype.
AB - In the analysis of non-Hodgkin's lymphomas (NHL), molecular techniques have become of increasing pratical importance both for diagnostic purposes, at disease onset, and in order to accurately evaluate prognosis, following specific therapies. Moreover, the presence of disease-specific or clonal abnormalities, such as chromosomal translocation, can provide markers for the detection of minimal residual disease (MRD). In this regard, a growing number of largely overlapping techniques including Southern blotting (SB), polymerase chain reaction (PCR) and fluorescent in-situ hybridization (FISH) are responsible for these advances. In view of these novel investigational possibilities, it is of paramount importance to evaluate correctly the specific role of each technique with respect to classical analyses investigating morphology, immunophenotype and karyotype.
KW - Chromosomal translocation
KW - Molecular boilogy
KW - Non-Hodgkin's Lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0035200285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035200285&partnerID=8YFLogxK
M3 - Articolo
VL - 22
SP - 21
EP - 28
JO - Impegno Ospedaliero, Sezione Scientifica
JF - Impegno Ospedaliero, Sezione Scientifica
SN - 0393-0394
IS - 5
ER -