Molecular diagnosis of opportunistic pericardial infection in a patient treated with adalimumab: The role of next-generation sequencing

Stefano Poli, Manola Comar, Roberto Luzzati, Gianfranco Sinagra

Research output: Contribution to journalArticle

Abstract

Biological immune-modulator drugs, especially inhibitors of tumor necrosis factor-α, are frequently encountered in modern clinical practice and opportunistic infections are therefore a common concern. Infective pericarditis has been described as a complication of these treatments with possible life-threatening consequences. In similar cases cultures may isolate multiple opportunistic bacteria from the pericardial fluid without specific identification of the responsible germ, representing a problem for targeted antibiotic therapy. We present a case of acute pericarditis evolving in pericardial constriction and cardiac tamponade in a patient treated with adalimumab for psoriatic arthritis overlapping with recurrent polychondritis. Next-generation sequencing allowed the identification of a common oral pathogen as the aetiological agent confirming its role in the identification of species that can be overlooked by common microbiological techniques.

Original languageEnglish
Article number215529
JournalBMJ Case Reports
Volume2016
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Medicine(all)

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