Molecular diagnostics by microelectronic microchips

Maurizio Ferrari; Laura Cremonesi; Pierangelo Bonini; Stefania Stenirri; Barbara Foglieni

doi:10.1586/14737159.5.2.183

Molecular diagnostics by microelectronic microchips

Maurizio Ferrari, Laura Cremonesi, Pierangelo Bonini, Stefania Stenirri, Barbara Foglieni

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Molecular diagnostics is being revolutionized by the development of highly advanced technologies for DNA and RNA testing. One of the most important challenges is the integration of microelectronics to microchip-based nucleic acid technologies. The specific characteristics of these microsystems make the miniaturization and automation of any step of a molecular diagnostic procedure possible. This review describes the application of microelectronics to all the processes involved in a genetic test, particularly to sample preparation, DNA amplification and sequence variation detection.

Original language	English
Pages (from-to)	183-192
Number of pages	10
Journal	Expert Review of Molecular Diagnostics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1586/14737159.5.2.183
Publication status	Published - Mar 2005

Keywords

DNA
Microchip
Microelectronics
Miniaturization
Mutation detection
PCR
SNP

ASJC Scopus subject areas

Genetics

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