Molecular diagnostics by microelectronic microchips

Maurizio Ferrari, Laura Cremonesi, Pierangelo Bonini, Stefania Stenirri, Barbara Foglieni

Research output: Contribution to journalArticlepeer-review

Abstract

Molecular diagnostics is being revolutionized by the development of highly advanced technologies for DNA and RNA testing. One of the most important challenges is the integration of microelectronics to microchip-based nucleic acid technologies. The specific characteristics of these microsystems make the miniaturization and automation of any step of a molecular diagnostic procedure possible. This review describes the application of microelectronics to all the processes involved in a genetic test, particularly to sample preparation, DNA amplification and sequence variation detection.

Original languageEnglish
Pages (from-to)183-192
Number of pages10
JournalExpert Review of Molecular Diagnostics
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 2005

Keywords

  • DNA
  • Microchip
  • Microelectronics
  • Miniaturization
  • Mutation detection
  • PCR
  • SNP

ASJC Scopus subject areas

  • Genetics

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