Molecular diversity of HIV in Albania

Massimo Ciccozzi, Caterina Gori, Stefano Boros, Maria Jose Ruiz-Alvarez, Arjan Harxhi, Marjeta Dervishi, Shpetim Qyra, Nicola Schinaia, Roberta D'Arrigo, Francesca Ceccherini-Silberstein, Silva Bino, Carlo Federico Perno, Giovanni Rezza

Research output: Contribution to journalArticlepeer-review


Little information is available on circulating human immunodeficiency virus (HIV) subtypes and resistance to antiretroviral drugs in Albania. To fill this gap, we studied 72 plasma samples from HIV-infected individuals from throughout the country. Subtype classification and genotypic resistance analysis were performed on the HIV pol gene region. The analysis was successfully performed on 66 (91.6%) plasma samples and showed that 43 (65.2%) strains were non-B subtypes (mostly subtype A, as determined by analysis of pol gene sequences). No major mutations in the protease gene were found, whereas analysis of the reverse transcriptase gene revealed a few major mutations associated with resistance. In conclusion, non-B subtypes are predominant in Albania, and the prevalence of resistance to antiretroviral drugs is still low.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalJournal of Infectious Diseases
Issue number3
Publication statusPublished - Aug 1 2005

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health


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