TY - JOUR
T1 - Molecular diversity of HIV in Albania
AU - Ciccozzi, Massimo
AU - Gori, Caterina
AU - Boros, Stefano
AU - Ruiz-Alvarez, Maria Jose
AU - Harxhi, Arjan
AU - Dervishi, Marjeta
AU - Qyra, Shpetim
AU - Schinaia, Nicola
AU - D'Arrigo, Roberta
AU - Ceccherini-Silberstein, Francesca
AU - Bino, Silva
AU - Perno, Carlo Federico
AU - Rezza, Giovanni
PY - 2005/8/1
Y1 - 2005/8/1
N2 - Little information is available on circulating human immunodeficiency virus (HIV) subtypes and resistance to antiretroviral drugs in Albania. To fill this gap, we studied 72 plasma samples from HIV-infected individuals from throughout the country. Subtype classification and genotypic resistance analysis were performed on the HIV pol gene region. The analysis was successfully performed on 66 (91.6%) plasma samples and showed that 43 (65.2%) strains were non-B subtypes (mostly subtype A, as determined by analysis of pol gene sequences). No major mutations in the protease gene were found, whereas analysis of the reverse transcriptase gene revealed a few major mutations associated with resistance. In conclusion, non-B subtypes are predominant in Albania, and the prevalence of resistance to antiretroviral drugs is still low.
AB - Little information is available on circulating human immunodeficiency virus (HIV) subtypes and resistance to antiretroviral drugs in Albania. To fill this gap, we studied 72 plasma samples from HIV-infected individuals from throughout the country. Subtype classification and genotypic resistance analysis were performed on the HIV pol gene region. The analysis was successfully performed on 66 (91.6%) plasma samples and showed that 43 (65.2%) strains were non-B subtypes (mostly subtype A, as determined by analysis of pol gene sequences). No major mutations in the protease gene were found, whereas analysis of the reverse transcriptase gene revealed a few major mutations associated with resistance. In conclusion, non-B subtypes are predominant in Albania, and the prevalence of resistance to antiretroviral drugs is still low.
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U2 - 10.1086/431599
DO - 10.1086/431599
M3 - Article
C2 - 15995961
AN - SCOPUS:22544438677
VL - 192
SP - 475
EP - 479
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -