Molecular diversity of HIV in Albania

Massimo Ciccozzi; Caterina Gori; Stefano Boros; Maria Jose Ruiz-Alvarez; Arjan Harxhi; Marjeta Dervishi; Shpetim Qyra; Nicola Schinaia; Roberta D'Arrigo; Francesca Ceccherini-Silberstein; Silva Bino; Carlo Federico Perno; Giovanni Rezza

doi:10.1086/431599

Molecular diversity of HIV in Albania

Massimo Ciccozzi, Caterina Gori, Stefano Boros, Maria Jose Ruiz-Alvarez, Arjan Harxhi, Marjeta Dervishi, Shpetim Qyra, Nicola Schinaia, Roberta D'Arrigo, Francesca Ceccherini-Silberstein, Silva Bino, Carlo Federico Perno, Giovanni Rezza

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Little information is available on circulating human immunodeficiency virus (HIV) subtypes and resistance to antiretroviral drugs in Albania. To fill this gap, we studied 72 plasma samples from HIV-infected individuals from throughout the country. Subtype classification and genotypic resistance analysis were performed on the HIV pol gene region. The analysis was successfully performed on 66 (91.6%) plasma samples and showed that 43 (65.2%) strains were non-B subtypes (mostly subtype A, as determined by analysis of pol gene sequences). No major mutations in the protease gene were found, whereas analysis of the reverse transcriptase gene revealed a few major mutations associated with resistance. In conclusion, non-B subtypes are predominant in Albania, and the prevalence of resistance to antiretroviral drugs is still low.

Original language	English
Pages (from-to)	475-479
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	192
Issue number	3
DOIs	https://doi.org/10.1086/431599
Publication status	Published - Aug 1 2005

ASJC Scopus subject areas

Immunology
Public Health, Environmental and Occupational Health

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Molecular diversity of HIV in Albania. / Ciccozzi, Massimo; Gori, Caterina; Boros, Stefano; Ruiz-Alvarez, Maria Jose; Harxhi, Arjan; Dervishi, Marjeta; Qyra, Shpetim; Schinaia, Nicola; D'Arrigo, Roberta; Ceccherini-Silberstein, Francesca; Bino, Silva; Perno, Carlo Federico; Rezza, Giovanni.

In: Journal of Infectious Diseases, Vol. 192, No. 3, 01.08.2005, p. 475-479.

Research output: Contribution to journal › Article › peer-review

Ciccozzi, Massimo ; Gori, Caterina ; Boros, Stefano ; Ruiz-Alvarez, Maria Jose ; Harxhi, Arjan ; Dervishi, Marjeta ; Qyra, Shpetim ; Schinaia, Nicola ; D'Arrigo, Roberta ; Ceccherini-Silberstein, Francesca ; Bino, Silva ; Perno, Carlo Federico ; Rezza, Giovanni. / Molecular diversity of HIV in Albania. In: Journal of Infectious Diseases. 2005 ; Vol. 192, No. 3. pp. 475-479.

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