Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique

Sofia O. Viegas, Adelina MacHado, Ramona Groenheit, Solomon Ghebremichael, Alexandra Pennhag, Paula S. Gudo, Zaina Cuna, Paolo Miotto, Véronique Hill, Tatiana Marrufo, Daniela M. Cirillo, Nalin Rastogi, Gunilla Källenius, Tuija Koivula

Research output: Contribution to journalArticle

Abstract

Abstract. Background. Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of Mycobacterium tuberculosis circulating in the country are important to better understand the epidemic. This study determined the predominant strain lineages that cause TB in Mozambique. Results. A total of 445 M. tuberculosis isolates from seven different provinces of Mozambique were characterized by spoligotyping and resulting profiles were compared with the international spoligotyping database SITVIT2. The four most predominant lineages observed were: the Latin-American Mediterranean (LAM, n = 165 or 37%); the East African-Indian (EAI, n = 132 or 29.7%); an evolutionary recent but yet ill-defined T clade, (n = 52 or 11.6%); and the globally-emerging Beijing clone, (n = 31 or 7%). A high spoligotype diversity was found for the EAI, LAM and T lineages. Conclusions. The TB epidemic in Mozambique is caused by a wide diversity of spoligotypes with predominance of LAM, EAI, T and Beijing lineages.

Original languageEnglish
Article number195
JournalBMC Microbiology
Volume10
DOIs
Publication statusPublished - 2010

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Mozambique
Pulmonary Tuberculosis
Mycobacterium tuberculosis
Tuberculosis
Africa South of the Sahara
Clone Cells
Genotype
Databases
lipoarabinomannan
Beijing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Viegas, S. O., MacHado, A., Groenheit, R., Ghebremichael, S., Pennhag, A., Gudo, P. S., ... Koivula, T. (2010). Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique. BMC Microbiology, 10, [195]. https://doi.org/10.1186/1471-2180-10-195

Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique. / Viegas, Sofia O.; MacHado, Adelina; Groenheit, Ramona; Ghebremichael, Solomon; Pennhag, Alexandra; Gudo, Paula S.; Cuna, Zaina; Miotto, Paolo; Hill, Véronique; Marrufo, Tatiana; Cirillo, Daniela M.; Rastogi, Nalin; Källenius, Gunilla; Koivula, Tuija.

In: BMC Microbiology, Vol. 10, 195, 2010.

Research output: Contribution to journalArticle

Viegas, SO, MacHado, A, Groenheit, R, Ghebremichael, S, Pennhag, A, Gudo, PS, Cuna, Z, Miotto, P, Hill, V, Marrufo, T, Cirillo, DM, Rastogi, N, Källenius, G & Koivula, T 2010, 'Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique', BMC Microbiology, vol. 10, 195. https://doi.org/10.1186/1471-2180-10-195
Viegas, Sofia O. ; MacHado, Adelina ; Groenheit, Ramona ; Ghebremichael, Solomon ; Pennhag, Alexandra ; Gudo, Paula S. ; Cuna, Zaina ; Miotto, Paolo ; Hill, Véronique ; Marrufo, Tatiana ; Cirillo, Daniela M. ; Rastogi, Nalin ; Källenius, Gunilla ; Koivula, Tuija. / Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique. In: BMC Microbiology. 2010 ; Vol. 10.
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AU - Gudo, Paula S.

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