Molecular epidemiology of HIV type 1 CRF02-AG in Cameroon and African patients living in Italy

Nazle Mendonca Collaço Véras, Maria Mercedes Santoro, Rebecca R. Gray, Andrew J. Tatem, Alessandra Lo Presti, Flaminia Olearo, Giulia Cappelli, Vittorio Colizzi, Desiré Takou, Judith Torimiro, Gianluca Russo, Annapaola Callegaro, Romina Salpini, Roberta D'Arrigo, Carlo Federico Perno, Maureen M. Goodenow, Massimo Ciccozzi, Marco Salemi

Research output: Contribution to journalArticle

Abstract

HIV-1 CRF02-AG accounts for >50% of infected individuals in Cameroon. CRF02-AG prevalence has been increasing both in Africa and Europe, particularly in Italy because of migrations from the sub-Saharan region. This study investigated the molecular epidemiology of CRF02-AG in Cameroon by employing Bayesian phylodynamics and analyzed the relationship between HIV-1 CRF02-AG isolates circulating in Italy and those prevalent in Africa to understand the link between the two epidemics. Among 291 Cameroonian reverse transcriptase sequences analyzed, about 70% clustered within three distinct clades, two of which shared a most recent common ancestor, all related to sequences from Western Africa. The major Cameroonian clades emerged during the mid-1970s and slowly spread during the next 30 years. Little or no geographic structure was detected within these clades. One of the major driving forces of the epidemic was likely the high accessibility between locations in Southern Cameroon contributing to the mobility of the population. The remaining Cameroonian sequences and the new strains isolated from Italian patients were interspersed mainly within West and Central African sequences in the tree, indicating a continuous exchange of CRF02-AG viral strains between Cameroon and other African countries, as well as multiple independent introductions in the Italian population. The evaluation of the spread of CRF02-AG may provide significant insight about the future dynamics of the Italian and European epidemic.

Original languageEnglish
Pages (from-to)1173-1182
Number of pages10
JournalAIDS Research and Human Retroviruses
Volume27
Issue number11
DOIs
Publication statusPublished - Nov 1 2011

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Cameroon
Molecular Epidemiology
Italy
HIV-1
Western Africa
RNA-Directed DNA Polymerase
Population

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Véras, N. M. C., Santoro, M. M., Gray, R. R., Tatem, A. J., Presti, A. L., Olearo, F., ... Salemi, M. (2011). Molecular epidemiology of HIV type 1 CRF02-AG in Cameroon and African patients living in Italy. AIDS Research and Human Retroviruses, 27(11), 1173-1182. https://doi.org/10.1089/aid.2010.0333

Molecular epidemiology of HIV type 1 CRF02-AG in Cameroon and African patients living in Italy. / Véras, Nazle Mendonca Collaço; Santoro, Maria Mercedes; Gray, Rebecca R.; Tatem, Andrew J.; Presti, Alessandra Lo; Olearo, Flaminia; Cappelli, Giulia; Colizzi, Vittorio; Takou, Desiré; Torimiro, Judith; Russo, Gianluca; Callegaro, Annapaola; Salpini, Romina; D'Arrigo, Roberta; Perno, Carlo Federico; Goodenow, Maureen M.; Ciccozzi, Massimo; Salemi, Marco.

In: AIDS Research and Human Retroviruses, Vol. 27, No. 11, 01.11.2011, p. 1173-1182.

Research output: Contribution to journalArticle

Véras, NMC, Santoro, MM, Gray, RR, Tatem, AJ, Presti, AL, Olearo, F, Cappelli, G, Colizzi, V, Takou, D, Torimiro, J, Russo, G, Callegaro, A, Salpini, R, D'Arrigo, R, Perno, CF, Goodenow, MM, Ciccozzi, M & Salemi, M 2011, 'Molecular epidemiology of HIV type 1 CRF02-AG in Cameroon and African patients living in Italy', AIDS Research and Human Retroviruses, vol. 27, no. 11, pp. 1173-1182. https://doi.org/10.1089/aid.2010.0333
Véras, Nazle Mendonca Collaço ; Santoro, Maria Mercedes ; Gray, Rebecca R. ; Tatem, Andrew J. ; Presti, Alessandra Lo ; Olearo, Flaminia ; Cappelli, Giulia ; Colizzi, Vittorio ; Takou, Desiré ; Torimiro, Judith ; Russo, Gianluca ; Callegaro, Annapaola ; Salpini, Romina ; D'Arrigo, Roberta ; Perno, Carlo Federico ; Goodenow, Maureen M. ; Ciccozzi, Massimo ; Salemi, Marco. / Molecular epidemiology of HIV type 1 CRF02-AG in Cameroon and African patients living in Italy. In: AIDS Research and Human Retroviruses. 2011 ; Vol. 27, No. 11. pp. 1173-1182.
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