Molecular epidemiology of human herpesvirus 8 variants in Kaposi's sarcoma from Iranian patients

Somayeh Jalilvand, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Buonaguro, Zahra Safaie Naraghi, Zabihollah Shoja, Abed Ali Ziaee, Rasool Hamkar, Shohreh Shahmahmoodi, Rakhshandeh Nategh, Talat Mokhtari-Azad

Research output: Contribution to journalArticlepeer-review

Abstract

Kaposi's sarcoma (KS) is a rare cancer in Iran and there is no epidemiological and molecular information about HHV-8 variants circulating among the Iranian population. In this study HHV-8 sequences have been analyzed in 43 cutaneous KS biopsies from Iranian patients mainly affected by classic KS. DNA samples were subjected to PCR amplification of HHV-8 ORF26, T0.7 and K1 followed by direct nucleotide sequencing and phylogenetic analysis. The analysis of ORF26 showed that 30 (69.8%) and 13 (30.2%) samples belonged to subtypes A/C and K, respectively. In general, the clustering of HHV-8 T0.7 variants paralleled that of ORF26. Genotyping of K1 sequences showed that the majority of samples (39 out of 41) fall into the large C clade with only 2 belonging to the A clade. In conclusion, HHV-8 variants identified among classic Iranian KS are largely related to Eurasian genotypes previously identified in KS from Mediterranean, Middle East, and East Asian regions.

Original languageEnglish
Pages (from-to)644-649
Number of pages6
JournalVirus Research
Volume163
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Human herpesvirus 8
  • Iran
  • Kaposi's sarcoma
  • ORF K1
  • ORF T0.7
  • ORF26

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

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