Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients

Maurizia Debiaggi, Filippo Canducci, Roberto Brerra, Michela Sampaolo, Maria Chiara Marinozzi, Maurizio Parea, Milena Arghittu, Emilio Paolo Alessandrino, Stefano Nava, Elisabetta Nucleo, Egidio Romero, Massimo Clementi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Polyomaviruses KI (KIPyV) and WU (WUPyV) were described recently in children with acute respiratory disease. The pathogenic potential of these human viruses has not been determined completely, but a correlation between immunosuppression and virus reactivation has been suggested. In the present study, the association between KI/WUPyV infection and immunosuppression was investigated using sequential nasopharyngeal aspirates from asymptomatic adult hematopoietic stem cell transplant recipients. In parallel, an investigation on the WU/KIPyV prevalence in children with acute respiratory disease was also carried out. Two of the 126 samples obtained from the 31 hematopoietic transplant recipients were positive for KIPyV (1 sample, 0.79%) and WUPyV (1 sample, 0.79%). Both samples were obtained 15 days after allogeneic transplantation and virus persistence was not observed in subsequent samples. In symptomatic children, 7 of the 486 nasopharyngeal aspirates were positive for WUPyV (1.4%) and 1 for KIPyV (0.2%). Single polyomavirus infection was detected in four patients, whereas the remaining patients were co-infected with respiratory syncityal virus (three patients) or adenovirus (one patient). The results suggest that WU/ KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalJournal of Medical Virology
Volume82
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Polyomavirus
Adult Stem Cells
Molecular Epidemiology
Acute Disease
Hematopoietic Stem Cells
Viruses
Transplants
Immunosuppression
Polyomavirus Infections
Asymptomatic Infections
Homologous Transplantation
Adenoviridae
Italy
Transplant Recipients
Infection

Keywords

  • Acute respiratory disease
  • Immunocompromised patients
  • KI polyomavirus
  • Respiratory viruses
  • WU polyomavirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients. / Debiaggi, Maurizia; Canducci, Filippo; Brerra, Roberto; Sampaolo, Michela; Marinozzi, Maria Chiara; Parea, Maurizio; Arghittu, Milena; Alessandrino, Emilio Paolo; Nava, Stefano; Nucleo, Elisabetta; Romero, Egidio; Clementi, Massimo.

In: Journal of Medical Virology, Vol. 82, No. 1, 01.2010, p. 153-156.

Research output: Contribution to journalArticle

Debiaggi, M, Canducci, F, Brerra, R, Sampaolo, M, Marinozzi, MC, Parea, M, Arghittu, M, Alessandrino, EP, Nava, S, Nucleo, E, Romero, E & Clementi, M 2010, 'Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients', Journal of Medical Virology, vol. 82, no. 1, pp. 153-156. https://doi.org/10.1002/jmv.21659
Debiaggi, Maurizia ; Canducci, Filippo ; Brerra, Roberto ; Sampaolo, Michela ; Marinozzi, Maria Chiara ; Parea, Maurizio ; Arghittu, Milena ; Alessandrino, Emilio Paolo ; Nava, Stefano ; Nucleo, Elisabetta ; Romero, Egidio ; Clementi, Massimo. / Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients. In: Journal of Medical Virology. 2010 ; Vol. 82, No. 1. pp. 153-156.
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